Attitudes Towards Vaccination Against COVID-19 During Pregnancy and Its Determinants Among People of Reproductive Age

Overview

Journal Hum Vaccin Immunother

Date 2025 Jan 11

PMID 39797690

Authors

Chenyuan Qin

Yansheng Ding

Min Liu

Jue Liu

Affiliations

Soon will be listed here.

Abstract

The attitudes of reproductive-age individuals toward COVID-19 vaccination during pregnancy are still not well understood. We aimed to explore the attitudes toward COVID-19 vaccines during pregnancy and the determinants among the Chinese reproductive-age population. An anonymous cross-sectional study was conducted in China from July 4 to August 11, 2023. Structured questionnaires on vaccine hesitancy during pregnancy, socio-demographic characteristics, behavior characteristics, health-related factors, and mental health status were sent online to reproductive-age individuals (both males and females). Among 2966 participants of reproductive age, 86.9% exhibited significant hesitancy toward receiving the COVID-19 vaccine during pregnancy. Participants of older age (30-34: aOR = 1.71, 95% CI: 1.62-2.52; 35-39: aOR = 1.72, 95% CI: 1.11-2.66), nonsmokers (aOR = 1.42, 95% CI: 1.07-1.89), with a longer duration since their last COVID-19 vaccination (aOR = 2.37, 95% CI: 1.20-4.70), and exhibiting marked pandemic fatigue (moderate: aOR = 1.98, 95% CI: 1.56-2.52; high: aOR = 3.49, 95% CI: 2.41-5.05) were prone to refuse COVID-19 vaccines during pregnancy. The presence of generalized anxiety disorder may push the vaccination (aOR = 0.75, 95% CI: 0.57-0.99). The top three reasons for hesitation were concerns about the adverse health effects of vaccines on pregnant women (77.72%), fetuses (72.13%), and newborns/infants (58.77%), respectively. Therefore, under the context of the existing circumstances and the WHO's encouragement, this study provides data support for possible future policy changes and emphasizes the importance of public health strategies.

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