β-Glucan Induced Plasma B Cells Differentiation to Enhance Antitumor Immune Responses by Dectin-1

Overview

Journal BMC Immunol

Publisher Biomed Central

Date 2025 Jan 10

PMID 39794756

Authors

Yu Bai

Jun Ding

Liuyang He

Zhichao Zhu

Jie Pan

Chunjian Qi

Affiliations

Soon will be listed here.

Abstract

Background: B lymphocytes, essential in cellular immunity as antigen-presenting cells and in humoral immunity as major effector cells, play a crucial role in the antitumor response. Our previous work has shown β-glucan enhanced immunoglobulins (Ig) secretion. But the specific mechanisms of B-cell activation with β-glucan are poorly understood. Here, we took advantage of β-glucan to improve the antitumor immune response of B cells.

Results: In vitro experiments demonstrate that β-glucan enhance the differentiation of B220 CD138 B cells, up-regulate co-stimulatory molecules, and increase the production of cytokines and Ig in response to various antigens. Using the Dectin-1 knockout mice, we revealed that β-glucan modulate B cell immune responses dependent on Dectin-1 receptor. In mouse models of Lewis lung cancer (LLC) tumors, combining β-glucan with programmed death-1(PD-1) blocking antibodies led to increase recruitment of CD19 B cells in the tumor microenvironment (TME), higher numbers of germinal centers B cells (GC B) in the spleen and draining lymph node (DLN), elevate Ig production, and delay tumor progression.

Conclusions: These findings reveal that β-glucan can serve as a potent adjuvant to modulate B cell immune responses in a Dectin-1 dependent manner and improve immune checkpoint blockade (ICB) therapy in antitumor.

Clinical Trial Number: Not applicable.

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