Association Between Daily Sitting Time and Sarcopenia in the US Population: a Cross-sectional Study

Overview

Journal Arch Public Health

Publisher Biomed Central

Date 2025 Jan 9

PMID 39789586

Authors

Alei Zhang

Yanlei Li

Jinlei Zhou

Yuan Zhang

Shanggao Xie

Haiyu Shao

Tingxiao Zhao

Tao Tang

Affiliations

Soon will be listed here.

Abstract

Background: Sarcopenia is an age-related syndrome marked by a gradual decline in skeletal muscle mass and function. While various factors influencing sarcopenia have been studied, the link between daily sedentary time and sarcopenia remains underexplored.

Method: This study analyzed the association between daily sitting time and sarcopenia using data from the National Health and Nutrition Examination Survey (NHANES 2011-2018). Daily sitting time was assessed through questionnaires, while sarcopenia was measured using body mass index (BMI) adjusted appendicular skeletal muscle mass (ASM). The relationship was analyzed using weighted logistic regression models and smoothing curves. Stratified analyses and interaction testing were employed to investigate population-specific characteristics of this association. Furthermore, chi-square test and grouped logistic regression were used to further analyze the impact of vigorous activity on the relationship between the two variables.

Result: This study included 9998 participants with complete information. The fully adjusted model showed a significant positive correlation between daily sitting time and the prevalence of sarcopenia (OR = 1.07, 95% CI: 1.03-1.10, P = 0.0026). The group with daily sitting time ≥ 9 h had a 90% higher risk of sarcopenia compared to the < 4 h group (OR = 1.90, 95% CI: 1.22-2.84, P = 0.0040). Smooth curve fitting analysis showed a linear correlation between this relationship. Stratified analysis shows that non-Hispanic white men with a lower BMI (BMI < 25) have a higher risk of sarcopenia. Compared to those who actively participate in vigorous activities, individuals who lack recreational activities have a higher prevalence and risk of sarcopenia.

Conclusion: Our research has found that increased sedentary time significantly increases the risk of sarcopenia, especially among non-Hispanic white men with lower BMI. Additionally, individuals who lack vigorous physical activity also have a higher prevalence and risk of sarcopenia. Therefore, reducing sedentary behavior and increasing moderate exercise may be effective prevention strategies.

References

Minniti G, Pescinini-Salzedas L, Minniti G, Fornari Laurindo L, Barbalho S, Sinatora R . Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise. Int J Mol Sci. 2022; 23(21). PMC: 9655425. DOI: 10.3390/ijms232113452. View

Pascual-Fernandez J, Fernandez-Montero A, Cordova-Martinez A, Pastor D, Martinez-Rodriguez A, Roche E . Sarcopenia: Molecular Pathways and Potential Targets for Intervention. Int J Mol Sci. 2020; 21(22). PMC: 7700275. DOI: 10.3390/ijms21228844. View

ORourke K . Higher sitting time increases the risk of all-cause, cancer-specific, and noncancer mortality. Cancer. 2022; 128(9):1722. DOI: 10.1002/cncr.34203. View

Tremblay M, Aubert S, Barnes J, Saunders T, Carson V, Latimer-Cheung A . Sedentary Behavior Research Network (SBRN) - Terminology Consensus Project process and outcome. Int J Behav Nutr Phys Act. 2017; 14(1):75. PMC: 5466781. DOI: 10.1186/s12966-017-0525-8. View

Studenski S, Peters K, Alley D, Cawthon P, McLean R, Harris T . The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci. 2014; 69(5):547-58. PMC: 3991146. DOI: 10.1093/gerona/glu010. View

Hida T, Harada A, Imagama S, Ishiguro N . Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations. Aging Dis. 2014; 5(4):226-37. PMC: 4113513. DOI: 10.14336/AD.2014.0500226. View

Rezende L, Rey-Lopez J, Matsudo V, Luiz O . Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health. 2014; 14:333. PMC: 4021060. DOI: 10.1186/1471-2458-14-333. View

Beaudart C, Zaaria M, Pasleau F, Reginster J, Bruyere O . Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLoS One. 2017; 12(1):e0169548. PMC: 5240970. DOI: 10.1371/journal.pone.0169548. View

Chen S, Xu X, Gong H, Chen R, Guan L, Yan X . Global epidemiological features and impact of osteosarcopenia: A comprehensive meta-analysis and systematic review. J Cachexia Sarcopenia Muscle. 2023; 15(1):8-20. PMC: 10834350. DOI: 10.1002/jcsm.13392. View

10.

Tiidus P . Benefits of estrogen replacement for skeletal muscle mass and function in post-menopausal females: evidence from human and animal studies. Eurasian J Med. 2015; 43(2):109-14. PMC: 4261347. DOI: 10.5152/eajm.2011.24. View

11.

Chhetri J, De Souto Barreto P, Fougere B, Rolland Y, Vellas B, Cesari M . Chronic inflammation and sarcopenia: A regenerative cell therapy perspective. Exp Gerontol. 2018; 103:115-123. DOI: 10.1016/j.exger.2017.12.023. View

12.

Strain T, Flaxman S, Guthold R, Semenova E, Cowan M, Riley L . National, regional, and global trends in insufficient physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5·7 million participants. Lancet Glob Health. 2024; 12(8):e1232-e1243. PMC: 11254784. DOI: 10.1016/S2214-109X(24)00150-5. View

13.

Patel H, Syddall H, Jameson K, Robinson S, Denison H, Roberts H . Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS). Age Ageing. 2013; 42(3):378-84. PMC: 3633365. DOI: 10.1093/ageing/afs197. View

14.

Cawthon P, Lui L, Taylor B, McCulloch C, Cauley J, Lapidus J . Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study. J Gerontol A Biol Sci Med Sci. 2017; 72(10):1383-1389. PMC: 5861971. DOI: 10.1093/gerona/glw327. View

15.

Matthews C, Keadle S, Troiano R, Kahle L, Koster A, Brychta R . Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults. Am J Clin Nutr. 2016; 104(5):1424-1432. PMC: 5081718. DOI: 10.3945/ajcn.116.135129. View

16.

Han P, Zhao J, Guo Q, Wang J, Zhang W, Shen S . Incidence, Risk Factors, and the Protective Effect of High Body Mass Index against Sarcopenia in Suburb-Dwelling Elderly Chinese Populations. J Nutr Health Aging. 2016; 20(10):1056-1060. DOI: 10.1007/s12603-016-0704-3. View

17.

Huang Q, Wan J, Nan W, Li S, He B, Peng Z . Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011-2018. J Hazard Mater. 2023; 464:133005. DOI: 10.1016/j.jhazmat.2023.133005. View

18.

Cruz-Jentoft A, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T . Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2018; 48(1):16-31. PMC: 6322506. DOI: 10.1093/ageing/afy169. View

19.

Dempsey P, Matthews C, Dashti S, Doherty A, Bergouignan A, van Roekel E . Sedentary Behavior and Chronic Disease: Mechanisms and Future Directions. J Phys Act Health. 2019; 17(1):52-61. DOI: 10.1123/jpah.2019-0377. View

20.

Mo Y, Zhou Y, Chan H, Evans C, Maddocks M . The association between sedentary behaviour and sarcopenia in older adults: a systematic review and meta-analysis. BMC Geriatr. 2023; 23(1):877. PMC: 10734096. DOI: 10.1186/s12877-023-04489-7. View