FLASH Radiotherapy: Mechanisms, Nanotherapeutic Strategy and Future Development

Overview

Journal Nanoscale Adv

Publisher Royal Society of Chemistry

Date 2025 Jan 9

PMID 39781242

Authors

Yan Wang

Huifang Wang

Jiawei Hu

Jingjing Chai

Jiajie Luan

Jie Li

Qingwen Xu

Affiliations

Soon will be listed here.

Abstract

Ultra-high dose-rate (FLASH) radiotherapy serves as an ideal procedure to treat tumors efficiently without harming normal tissues and has demonstrated satisfactory antitumor effects in multiple animal tumor models. However, the biological mechanisms of FLASH radiotherapy have not yet been fully elucidated, and the small number of devices delivering FLASH dose rate has limited its wide application. This review summarizes the possible biological mechanisms and antitumor effects of FLASH radiotherapy, its application in nanotherapeutic strategy, as well as its challenges and future development. Furthermore, some valuable guidance for promoting the progress of FLASH radiotherapy in nanotherapeutic strategies are provided.

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