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VR Cognitive-based Intervention for Enhancing Cognitive Functions and Well-being in Older Adults with Mild Cognitive Impairment: Behavioral and EEG Evidence

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Date 2025 Jan 9
PMID 39781014
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Abstract

Mild cognitive impairment (MCI) has been recognized as a window of opportunity for therapeutic and preventive measures to slow cognitive decline. The current study investigated the efficacy of the virtual reality (VR) cognitive-based intervention on verbal and visuospatial short-term memory (STM), executive functions (EFs), and wellbeing among older adults with and without MCI. The immersive VR cognitive-based intervention comprised eight 60-minute sessions, held twice a week over a span of 30 days. The participants consisted of 31 non-MCI older adults in the experimental group (mean age ± = 66.31 ± 3.12 years), 29 older adults with MCI in the experimental group (mean age ± = 68.19 ± 5.03 years), and 30 non-MCI older adults in the control group (mean age ± = 64.97 ± 3.35 years). The dependent variables were assessed by using a battery of computerized test, the well-being of older people questionnaire and resting-state EEG. A repeated-measures ANCOVA was employed to examine the effects of the developed VR intervention. Significant improvements were observed in both STMs and EFs following the intervention, as indicated by behavioral and EEG findings, ranging from small to large effect sizes (i.e., = .05-.17). However, enhanced wellbeing was specifically observed among older adults with MCI in the experimental group, (2, 87) = 6.78, .01, = .11. The present findings lend support to the efficacy of VR cognitive-based interventions across clinical and non-clinical populations. These results underscore the immediate impact of the intervention across multimodal assessments, including neurophysiological changes, cognitive, and behavioral outcomes.

References
1.
Zuschnegg J, Schoberer D, Haussl A, Herzog S, Russegger S, Ploder K . Effectiveness of computer-based interventions for community-dwelling people with cognitive decline: a systematic review with meta-analyses. BMC Geriatr. 2023; 23(1):229. PMC: 10091663. DOI: 10.1186/s12877-023-03941-y. View

2.
Mueller S, Piper B . The Psychology Experiment Building Language (PEBL) and PEBL Test Battery. J Neurosci Methods. 2013; 222:250-9. PMC: 3897935. DOI: 10.1016/j.jneumeth.2013.10.024. View

3.
Hackert M, van Exel J, Brouwer W . Well-being of Older People (WOOP): Quantitative validation of a new outcome measure for use in economic evaluations. Soc Sci Med. 2020; 259:113109. DOI: 10.1016/j.socscimed.2020.113109. View

4.
Jonson M, Avramescu S, Chen D, Alam F . The Role of Virtual Reality in Screening, Diagnosing, and Rehabilitating Spatial Memory Deficits. Front Hum Neurosci. 2021; 15:628818. PMC: 7893135. DOI: 10.3389/fnhum.2021.628818. View

5.
Wutzl B, Leibnitz K, Kominami D, Ohsita Y, Kaihotsu M, Murata M . Analysis of the Correlation between Frontal Alpha Asymmetry of Electroencephalography and Short-Term Subjective Well-Being Changes. Sensors (Basel). 2023; 23(15). PMC: 10422288. DOI: 10.3390/s23157006. View