Controls Wing Developmental Growth by Targeting

Overview

Journal Anim Cells Syst (Seoul)

Date 2025 Jan 8

PMID 39777023

Authors

Chae Jeong Kim

Daegyu Jang

Do-Hwan Lim

Affiliations

Soon will be listed here.

Abstract

Tissue growth is controlled by various signaling pathways, such as the insulin/IGF-signaling (IIS) pathway. Although IIS activation is regulated by a complex regulatory network, the mechanism underlying miRNA-based regulation of the IIS pathway in wing development remains unclear. In this study, we found that the wing size of adult flies was negatively affected by miR-263b expression. The miR-263b-mediated alteration in wing size was linked to a reduction in wing cell number. Additionally, overexpression in S2 cells decreased cell proliferation and increased cell death. Consequently, we identified as a direct target of miR-263b-5p and found that miR-263b-mediated wing growth regulation was due to changes in expression. Co-expression of in -overexpressing wings rescued the overexpression-mediated reduction in wing growth. These results enhance our understanding of the crucial role of miRNAs in growth regulation during wing development.

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