Relevance of Perioperative Fluid Dynamics in Liver Transplantation to Acute Kidney Injury and Patient Outcomes: a Cross-sectional Survey

Overview

Journal J Pharm Policy Pract

Date 2025 Jan 8

PMID 39776465

Authors

Desheng Li

Qinghua Guan

Chuanlin Chen

Bo Sheng

Zhenyu Zhang

Yongfang Hu

Affiliations

Soon will be listed here.

Abstract

Background: Fluid administration is a critical component of perioperative management for liver transplant recipients, and excessive fluid infusion can lead to acute kidney injury (AKI) and poor patient outcomes.

Method: We conducted a cross-sectional survey on the fluid intake and output of adult liver transplant recipients over a 7-day period. The patients were divided into AKI and non-AKI groups. Multivariate logistic regression analyses were used to evaluate the association between fluid balance (FB) and AKI. A Kaplan-Meier survival analysis was performed to determine the survival of the recipient survival at 180 days.

Results: A total of 210 liver transplant recipients were included. The peak FB occurred on the second day after transplantation, which was higher than on the seventh day (0.3 [, -0.2 to 0.8] L vs. -0.4 [, -1.0 to 0.3] L, < 0.001). The highest incidence of AKI was observed on the second day after transplantation and the lowest on the seventh day (52.4% vs. 15.4%, < 0.001). Multivariate analysis showed that a cumulative FB > 1 L within the first 2 days postoperatively was an independent risk factor for AKI on the second day after liver transplantation (LT) ( = 2.66, % , 1.31-5.41, = 0.007). Survival analysis indicated significant differences in 180-day survival rates among patients with different grades of AKI [94.0% (grade 1) vs. 91.4% (grade 2) vs. 77.8% (grade 3), = 12.93, < 0.001].

Conclusion: There is a significant correlation between post-LT AKI and perioperative FB. Cumulative FB > 1 L in the first 2 days postoperatively is an independent risk factor for AKI on the second day after LT. AKI after LT is associated with a lower 180-day survival rate in patients.

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