LncRNA-miRNA-mRNA Regulatory Axes As Potential Biomarkers in Cervical Cancer: a Comprehensive Overview

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2025 Jan 8

PMID 39775991

Authors

Dimple Patel

Sanu Thankachan

Saraswathy Sreeram

K P Kavitha

Shama Prasada Kabekkodu

Padmanaban S Suresh

Affiliations

Soon will be listed here.

Abstract

Despite the recent advances in vaccination and treatment strategies, cervical cancer continues to claim numerous lives every year. Owing to the fact that non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with coding transcripts, and effectuate key roles in the tumorigenesis and metastasis of cervical cancer, there has been extensive research in recent years to explore their potential as biomarkers for early detection, or as therapeutic targets. Through this review, we aim to provide a comprehensive overview of the recent advancements in discoveries about cervical cancer-associated lncRNA-miRNA-mRNA axes, their dysregulation, and their roles in various signaling pathways associated with the growth, survival, invasion, and metastasis of cervical cancer cells. We further discuss the potential therapeutic strategies to utilize the dysregulated lncRNAs as diagnostic and prognostic biomarkers, and as therapeutic targets to ameliorate the prognosis of cervical cancer.

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