Vitamin A and Its Influence on Tumour Extracellular Matrix

Overview

Journal Discov Oncol

Publisher Springer

Specialty Oncology

Date 2025 Jan 8

PMID 39775988

Authors

Guoqing Xie

Shun Cao

Guangchun Wang

Xianzhong Zhang

Yu Zhang

Haofan Wu

Shuxian Shen

Jiandong Le

Keqiang Li

Zhenlin Huang

Affiliations

Soon will be listed here.

Abstract

Vitamin A is a crucial nutrient renowned for its role in visual health and cellular regulation. Its derivatives influence cell differentiation, proliferation, and tissue homeostasis, making them significant in cancer research due to their effects on both normal and tumour cells. This review explores the intricate relationship between vitamin A metabolism and the extracellular matrix (ECM) in cancer. The ECM profoundly affects tumour behaviour, including proliferation, invasion, and metastasis. Alterations in the ECM can facilitate tumour progression, and vitamin A derivatives have shown potential in modulating these changes. Through transcriptional regulation, vitamin A impacts ECM components and matrix metalloproteinases, influencing tumour dynamics. The review highlights the potential of vitamin A and its derivatives as adjunctive agents in cancer therapy. Despite promising laboratory findings, their clinical application remains limited due to challenges in translating these effects into therapeutic outcomes. Future research should focus on the modulation of retinol metabolism within tumours and the development of targeted therapies to enhance treatment efficacy and improve patient prognosis.

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