The Roles of DMT1 in Inflammatory and Degenerative Diseases

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2025 Jan 8

PMID 39775481

Authors

Haigang Liu

Mi Li

Yi Deng

Yanjun Hou

Liangcai Hou

Xiong Zhang

Zehang Zheng

Fengjing Guo

Kai Sun

Affiliations

Soon will be listed here.

Abstract

Iron homeostasis is critical for multiple physiological and pathological processes. DMT1, a core iron transporter, is expressed in almost all cells and organs and altered in response to various conditions, whereas, there is few reviews focusing on DMT1 in diseases associated with aberrant iron metabolism. Based on available knowledge, this review described a full view of DMT1 and summarized the roles of DMT1 and DMT1-mediated iron metabolism in the onset and development of inflammatory and degenerative diseases. This review also provided an overview of DMT1-related treatment in these disorders, highlighting its therapeutic potential in chronic inflammatory and degenerative diseases.

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