Aortic Body Tumor with Intracardiac Metastasis in a Dog

Overview

Journal J Vet Diagn Invest

Specialty Veterinary Medicine

Date 2025 Jan 8

PMID 39773166

Authors

Matthew I Crawford-Jennings

Lezith D Chavez

Emma R Loessberg

Francisco R Carvallo-Chaigneau

Affiliations

Soon will be listed here.

Abstract

A 9-y-old, spayed female, non-brachycephalic mixed-breed dog was presented with progressive abdominal distension and diarrhea of <24 h duration. An echocardiogram revealed nodular masses in the pericardium and myocardium, particularly near the auricles. Diagnostic and therapeutic pericardiocentesis failed to improve the dog's status, and the owner elected euthanasia. The autopsy revealed numerous nodules within the pericardium, heart base, and myocardium of the left and right ventricles. Histopathology revealed the presence of a neuroendocrine tumor, immunopositive for chromogranin A and negative for synaptophysin and calcitonin, supporting the diagnosis of aortic body tumor with intracardiac metastasis.

References

Nova-Camacho L, Gomez-Dorronsoro M, Guarch R, Cordoba A, Cevallos M, Panizo-Santos A . Cardiac Metastasis From Solid Cancers: A 35-Year Single-Center Autopsy Study. Arch Pathol Lab Med. 2022; 147(2):177-184. DOI: 10.5858/arpa.2021-0418-OA. View

Treggiari E, Pedro B, Dukes-McEwan J, Gelzer A, Blackwood L . A descriptive review of cardiac tumours in dogs and cats. Vet Comp Oncol. 2015; 15(2):273-288. DOI: 10.1111/vco.12167. View

Goldberg A, Blankstein R, Padera R . Tumors metastatic to the heart. Circulation. 2013; 128(16):1790-4. DOI: 10.1161/CIRCULATIONAHA.112.000790. View

MacDonald K, Cagney O, Magne M . Echocardiographic and clinicopathologic characterization of pericardial effusion in dogs: 107 cases (1985-2006). J Am Vet Med Assoc. 2009; 235(12):1456-61. DOI: 10.2460/javma.235.12.1456. View

Deim Z, Szalay F, Glavits R, Bauer A, Cserni G . Carotid body tumor in dog: a case report. Can Vet J. 2007; 48(8):865-7. PMC: 1914329. View

Yates W, Lester S, Mills J . Chemoreceptor tumors diagnosed at the Western College of Veterinary Medicine 1967-1979. Can Vet J. 1980; 21(4):124-9. PMC: 1789750. View

Noszczyk-Nowak A, Nowak M, Paslawska U, Atamaniuk W, Nicpon J . Cases with manifestation of chemodectoma diagnosed in dogs in Department of Internal Diseases with Horses, Dogs and Cats Clinic, Veterinary Medicine Faculty, University of Environmental and Life Sciences, Wroclaw, Poland. Acta Vet Scand. 2010; 52:35. PMC: 2886050. DOI: 10.1186/1751-0147-52-35. View

Cho K, Park N, Park I, Kang B, Onuma M . Metastatic intracavitary cardiac aortic body tumor in a dog. J Vet Med Sci. 1998; 60(11):1251-3. DOI: 10.1292/jvms.60.1251. View

Tomita T . Significance of chromogranin A and synaptophysin in medullary thyroid carcinoma. Bosn J Basic Med Sci. 2021; 21(5):535-541. PMC: 8381211. DOI: 10.17305/bjbms.2020.5407. View

10.

Saldana M, SALEM L, TRAVEZAN R . High altitude hypoxia and chemodectomas. Hum Pathol. 1973; 4(2):251-63. DOI: 10.1016/s0046-8177(73)80012-7. View

11.

Bussani R, De-Giorgio F, Abbate A, Silvestri F . Cardiac metastases. J Clin Pathol. 2006; 60(1):27-34. PMC: 1860601. DOI: 10.1136/jcp.2005.035105. View

12.

Naude S, Miller D . Magnetic resonance imaging findings of a metastatic chemodectoma in a dog. J S Afr Vet Assoc. 2006; 77(3):155-9. DOI: 10.4102/jsava.v77i3.365. View

13.

Yamamoto S, Hoshi K, Hirakawa A, Chimura S, Kobayashi M, Machida N . Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases. J Vet Med Sci. 2013; 75(11):1433-41. PMC: 3942993. DOI: 10.1292/jvms.13-0064. View

14.

Brown P, Rema A, Gartner F . Immunohistochemical characteristics of canine aortic and carotid body tumours. J Vet Med A Physiol Pathol Clin Med. 2003; 50(3):140-4. DOI: 10.1046/j.1439-0442.2003.00498.x. View

15.

Saunders R, Kraipowich N, Marshall H . Intracardiac malignant nonchromaffin paraganglioma (chemodectoma) in a cat. J Vet Cardiol. 2021; 37:1-7. DOI: 10.1016/j.jvc.2021.07.002. View

16.

Montgomery D, Bendele R, Storts R . Malignant aortic body tumor with metastasis to bone in a dog. Vet Pathol. 1980; 17(2):241-4. DOI: 10.1177/030098588001700214. View