Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan

Overview

Journal Nutrients

Date 2025 Jan 8

PMID 39771045

Authors

Hye-Yeon Lee

Kyung-Jin Min

Affiliations

Soon will be listed here.

Abstract

Dietary restriction (DR) has been reported to be a significant intervention that influences lipid metabolism and potentially modulates the aging process in a wide range of organisms. Lipid metabolism plays a pivotal role in the regulation of aging and longevity. In this review, we summarize studies on the significant role of lipid metabolism in aging in relation to DR. As a potent intervention to slow down aging, DR has demonstrated promising effects on lipid metabolism, influencing the aging processes across various species. The current review focuses on the relationships among DR-related molecular signaling proteins such as the sirtuins, signaling pathways such as the target of rapamycin and the insulin/insulin-like growth factor (IGF)-1, lipid metabolism, and aging. Furthermore, the review presents research results on diet-associated changes in cell membrane lipids and alterations in lipid metabolism caused by commensal bacteria, highlighting the importance of lipid metabolism in aging. Overall, the review explores the interplay between diet, lipid metabolism, and aging, while presenting untapped areas for further understanding of the aging process.

Citing Articles

Epigenetic Landscapes of Aging in Breast Cancer Survivors: Unraveling the Impact of Therapeutic Interventions-A Scoping Review.

Nikita N, Sun Z, Sharma S, Shaver A, Seewaldt V, Lu-Yao G Cancers (Basel). 2025; 17(5).

PMID: 40075712 PMC: 11899678. DOI: 10.3390/cancers17050866.

References

Cheng C, Gao T, Wang Z, Li D . Role of insulin/insulin-like growth factor 1 signaling pathway in longevity. World J Gastroenterol. 2005; 11(13):1891-5. PMC: 4305707. DOI: 10.3748/wjg.v11.i13.1891. View

Tontonoz P, Spiegelman B . Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008; 77:289-312. DOI: 10.1146/annurev.biochem.77.061307.091829. View

Ahn J, Cho I, Kim S, Kwon D, Ha T . Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet. J Hepatol. 2008; 49(6):1019-28. DOI: 10.1016/j.jhep.2008.08.012. View

Jobson R, Nabholz B, Galtier N . An evolutionary genome scan for longevity-related natural selection in mammals. Mol Biol Evol. 2009; 27(4):840-7. DOI: 10.1093/molbev/msp293. View

Lee H, Lee S, Lee J, Lee W, Min K . The role of commensal microbes in the lifespan of . Aging (Albany NY). 2019; 11(13):4611-4640. PMC: 6660043. DOI: 10.18632/aging.102073. View

Buttemer W, Battam H, Hulbert A . Fowl play and the price of petrel: long-living Procellariiformes have peroxidation-resistant membrane composition compared with short-living Galliformes. Biol Lett. 2008; 4(4):351-4. PMC: 2610141. DOI: 10.1098/rsbl.2008.0145. View

Hong J, Mei C, Raza S, Khan R, Cheng G, Zan L . SIRT6 cooperates with SIRT5 to regulate bovine preadipocyte differentiation and lipid metabolism via the AMPKα signaling pathway. Arch Biochem Biophys. 2020; 681:108260. DOI: 10.1016/j.abb.2020.108260. View

Holczer M, Hajdu B, Lorincz T, Szarka A, Banhegyi G, Kapuy O . Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation. Sci Rep. 2020; 10(1):17803. PMC: 7576158. DOI: 10.1038/s41598-020-75030-8. View

Plaisance E, Greenway F, Boudreau A, Hill K, Johnson W, Krajcik R . Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. J Clin Endocrinol Metab. 2011; 96(5):E836-40. PMC: 3085194. DOI: 10.1210/jc.2010-2493. View

10.

Lomb D, Laurent G, Haigis M . Sirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta. 2009; 1804(8):1652-7. DOI: 10.1016/j.bbapap.2009.11.021. View

11.

Levin G, Cogan U, Mokady S . Food restriction and membrane fluidity. Mech Ageing Dev. 1992; 62(2):137-41. DOI: 10.1016/0047-6374(92)90050-n. View

12.

Vo N, Zhang Q, Sung H . From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling. J Pharm Pharm Sci. 2024; 27:13062. PMC: 11298356. DOI: 10.3389/jpps.2024.13062. View

13.

Houde V, Brule S, Festuccia W, Blanchard P, Bellmann K, Deshaies Y . Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes. 2010; 59(6):1338-48. PMC: 2874694. DOI: 10.2337/db09-1324. View

14.

Soliman G, Acosta-Jaquez H, Fingar D . mTORC1 inhibition via rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes. Lipids. 2010; 45(12):1089-100. PMC: 5560266. DOI: 10.1007/s11745-010-3488-y. View

15.

Klass M . A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech Ageing Dev. 1983; 22(3-4):279-86. DOI: 10.1016/0047-6374(83)90082-9. View

16.

Fulco M, Sartorelli V . Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle. 2008; 7(23):3669-79. PMC: 2607479. DOI: 10.4161/cc.7.23.7164. View

17.

Wallis K, Melnyk S, Miousse I . Sex-Specific Effects of Dietary Methionine Restriction on the Intestinal Microbiome. Nutrients. 2020; 12(3). PMC: 7146121. DOI: 10.3390/nu12030781. View

18.

Szwed A, Kim E, Jacinto E . Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev. 2021; 101(3):1371-1426. PMC: 8424549. DOI: 10.1152/physrev.00026.2020. View

19.

KriZova E, Simek V . Effect of intermittent feeding with high-fat diet on changes of glycogen, protein and fat content in liver and skeletal muscle in the laboratory mouse. Physiol Res. 1996; 45(5):379-83. View

20.

Volek J, Fernandez M, Feinman R, Phinney S . Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome. Prog Lipid Res. 2008; 47(5):307-18. DOI: 10.1016/j.plipres.2008.02.003. View