Coffee and Cardiovascular Health: A Review of Literature

Overview

Journal Nutrients

Date 2025 Jan 8

PMID 39770879

Authors

Altaf Farraj

TiJesu Akeredolu

Anisha Wijeyesekera

Charlotte E Mills

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease is the leading cause of death worldwide and is on the rise. Diet is considered to be a key modifiable risk factor for reducing the incidence of cardiovascular disease. Dietary approaches have proved advantageous for preventing disease morbidity and mortality but tend to focus on fruit, vegetables, fiber, lean protein and healthy fats. Coffee is one of the most popular beverages worldwide but is often surrounded by controversy with regard to its impact on health. This review aims to explore the relationship between coffee consumption and cardiovascular disease. The evidence from observational trials as well as randomized controlled trials is discussed. By focusing on specific bioactive compounds in coffee, potential mechanisms are explored, and future directions of research in the field are considered.

References

Aguiar Jr A, Speck A, Canas P, Cunha R . Neuronal adenosine A receptors signal ergogenic effects of caffeine. Sci Rep. 2020; 10(1):13414. PMC: 7415152. DOI: 10.1038/s41598-020-69660-1. View

Blanchard J, Sawers S . The absolute bioavailability of caffeine in man. Eur J Clin Pharmacol. 1983; 24(1):93-8. DOI: 10.1007/BF00613933. View

Derossi A, Ricci I, Caporizzi R, Fiore A, Severini C . How grinding level and brewing method (Espresso, American, Turkish) could affect the antioxidant activity and bioactive compounds in a coffee cup. J Sci Food Agric. 2017; 98(8):3198-3207. DOI: 10.1002/jsfa.8826. View

Ha H, Chen J, Krahenbuhl S, Follath F . Biotransformation of caffeine by cDNA-expressed human cytochromes P-450. Eur J Clin Pharmacol. 1996; 49(4):309-15. DOI: 10.1007/BF00226333. View

Martins P, Batista N, da Cruz Pedrozo Miguel M, Simao J, Soares J, Schwan R . Coffee growing altitude influences the microbiota, chemical compounds and the quality of fermented coffees. Food Res Int. 2020; 129:108872. DOI: 10.1016/j.foodres.2019.108872. View

Shahinfar H, Jayedi A, Khan T, Shab-Bidar S . Coffee consumption and cardiovascular diseases and mortality in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis. 2021; 31(9):2526-2538. DOI: 10.1016/j.numecd.2021.05.014. View

Martinez-Lopez S, Sarria B, Mateos R, Bravo-Clemente L . Moderate consumption of a soluble green/roasted coffee rich in caffeoylquinic acids reduces cardiovascular risk markers: results from a randomized, cross-over, controlled trial in healthy and hypercholesterolemic subjects. Eur J Nutr. 2018; 58(2):865-878. DOI: 10.1007/s00394-018-1726-x. View

Diab A, Dastmalchi L, Gulati M, Michos E . A Heart-Healthy Diet for Cardiovascular Disease Prevention: Where Are We Now?. Vasc Health Risk Manag. 2023; 19:237-253. PMC: 10128075. DOI: 10.2147/VHRM.S379874. View

Cicero A, Fogacci F, DAddato S, Grandi E, Rizzoli E, Borghi C . Self-Reported Coffee Consumption and Central and Peripheral Blood Pressure in the Cohort of the Brisighella Heart Study. Nutrients. 2023; 15(2). PMC: 9862483. DOI: 10.3390/nu15020312. View

10.

Saraiva S, Jacinto T, Goncalves A, Gaspar D, Silva L . Overview of Caffeine Effects on Human Health and Emerging Delivery Strategies. Pharmaceuticals (Basel). 2023; 16(8). PMC: 10459237. DOI: 10.3390/ph16081067. View

11.

Guertin K, Loftfield E, Boca S, Sampson J, Moore S, Xiao Q . Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer. Am J Clin Nutr. 2015; 101(5):1000-11. PMC: 4409687. DOI: 10.3945/ajcn.114.096099. View

12.

Buscemi S, Verga S, Batsis J, Donatelli M, Tranchina M, Belmonte S . Acute effects of coffee on endothelial function in healthy subjects. Eur J Clin Nutr. 2010; 64(5):483-9. DOI: 10.1038/ejcn.2010.9. View

13.

Lang R, Dieminger N, Beusch A, Lee Y, Dunkel A, Suess B . Bioappearance and pharmacokinetics of bioactives upon coffee consumption. Anal Bioanal Chem. 2013; 405(26):8487-503. DOI: 10.1007/s00216-013-7288-0. View

14.

Ren Y, Wang C, Xu J, Wang S . Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. Int J Mol Sci. 2019; 20(17). PMC: 6747192. DOI: 10.3390/ijms20174238. View

15.

Mills C, Oruna-Concha M, Mottram D, Gibson G, Spencer J . The effect of processing on chlorogenic acid content of commercially available coffee. Food Chem. 2013; 141(4):3335-40. DOI: 10.1016/j.foodchem.2013.06.014. View

16.

Bjorngaard J, Nordestgaard A, Taylor A, Treur J, Gabrielsen M, Munafo M . Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis. Int J Epidemiol. 2017; 46(6):1958-1967. PMC: 5837196. DOI: 10.1093/ije/dyx147. View

17.

Abtan J, Ducrocq G, Elbez Y, Ferrari R, Ford I, Fox K . Association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease: Analysis from the CLARIFY registry. Arch Cardiovasc Dis. 2023; 116(8-9):382-389. DOI: 10.1016/j.acvd.2023.05.007. View

18.

Bonaa K, Arnesen E, Thelle D, Forde O . Coffee and cholesterol: is it all in the brewing? The Tromsø Study. BMJ. 1988; 297(6656):1103-4. PMC: 1834887. DOI: 10.1136/bmj.297.6656.1103. View

19.

Rasmussen B, Brix T, Kyvik K, Brosen K . The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics. 2002; 12(6):473-8. DOI: 10.1097/00008571-200208000-00008. View

20.

Cruchten S, de Waart D, Kunne C, Hooiveld G, Boekschoten M, Katan M . Absorption, distribution, and biliary excretion of cafestol, a potent cholesterol-elevating compound in unfiltered coffees, in mice. Drug Metab Dispos. 2010; 38(4):635-40. DOI: 10.1124/dmd.109.030213. View