The Killer Toxin: From Origin to Biomedical Research

Overview

Journal Microorganisms

Specialty Microbiology

Date 2025 Jan 8

PMID 39770684

Authors

Carlos Molina-Vera

Veronica Morales-Tlalpan

Amairani Chavez-Vega

Jennifer Uribe-Lopez

Jessica Trujillo-Barrientos

Juan Campos-Guillen

Jorge Luis Chavez-Servin

Teresa Garcia-Gasca

Carlos Saldana

Affiliations

Soon will be listed here.

Abstract

The systems of are defined by the co-infection of two viral agents, an M virus and a helper virus. Each toxin is determined by the type of M virus (ScV-M1, ScV-M2, ScV-M28, and ScV-Mlus), which encodes a specific toxin (K1, K2, K28, and Klus). Since their discovery, interest in their potential use as antimicrobial agents has driven research into the mechanisms of action of these toxins on susceptible cells. This review provides an overview of the key aspects of toxins, including their origin and the evolutionary implications surrounding the viruses involved in the system, as well as their potential applications in the biomedical field and as a biological control strategy. Special attention is given to the mechanisms of action described to date for the various toxins.

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