The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Jan 8

PMID 39769250

Authors

Mihaela Butiulca

Lenard Farczadi

Camil Eugen Vari

Silvia Imre

Leonard Azamfirei

Alexandra Lazar

Affiliations

Soon will be listed here.

Abstract

Ropivacaine, a widely used regional anesthetic also used for pain management, has been increasingly used in recent years due to its increased efficacy and improved safety compared to similar anesthetics. Biomonitoring of ropivacaine and its metabolites during and after anesthesia is an essential process for ensuring therapeutic efficacy and safe usage for patients. The most useful biomonitoring tool in recent years has been liquid chromatography coupled with mass spectrometry (LC-MS/MS), which offers selectivity, sensitivity, as well as accuracy of measurements. The current manuscript summarizes and discusses the existing liquid chromatographic methods described in the literature, as well as the personal experience with developing bioanalytical and analytical methods for the quantification of ropivacaine in biological samples for clinical applications. It is focused on methodological aspects, recent advancements, challenges, and future perspectives, highlighting the importance of LC-MS/MS techniques in ropivacaine analysis.

References

Abdel-Rehim M, Altun Z, Blomberg L . Microextraction in packed syringe (MEPS) for liquid and gas chromatographic applications. Part II--Determination of ropivacaine and its metabolites in human plasma samples using MEPS with liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2004; 39(12):1488-93. DOI: 10.1002/jms.731. View

Graf B, Abraham I, Eberbach N, Kunst G, Stowe D, Martin E . Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. Anesthesiology. 2002; 96(6):1427-34. DOI: 10.1097/00000542-200206000-00023. View

Yu Z, Abdel-Rehim M, Westerlund D . Determination of amide-type local anaesthetics by direct injection of plasma in a column-switching high-performance liquid chromatographic system using a pre-column with a semipermeable surface. J Chromatogr B Biomed Appl. 1994; 654(2):221-30. DOI: 10.1016/0378-4347(93)e0454-x. View

Neal J, Barrington M, Fettiplace M, Gitman M, Memtsoudis S, Morwald E . The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017. Reg Anesth Pain Med. 2018; 43(2):113-123. DOI: 10.1097/AAP.0000000000000720. View

Guidi M, Csajka C, Buclin T . Parametric Approaches in Population Pharmacokinetics. J Clin Pharmacol. 2020; 62(2):125-141. DOI: 10.1002/jcph.1633. View

Mouzi L, Adams O, Cuff G, Lukasiewicz E, Champeil E, Atchabahian A . Plasma concentrations of ropivacaine following ultrasound-guided or nerve-stimulator-guided femoral nerve block: A prospective randomised study. Anaesth Crit Care Pain Med. 2015; 35(1):45-48. DOI: 10.1016/j.accpm.2015.08.002. View

Tonooka K, Naruki N, Honma K, Agei K, Okutsu M, Hosono T . Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of nine local anesthetic drugs. Forensic Sci Int. 2016; 265:182-5. DOI: 10.1016/j.forsciint.2016.02.044. View

Koehler A, Oertel R, Kirch W . Simultaneous determination of bupivacaine, mepivacain, prilocaine and ropivacain in human serum by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2005; 1088(1-2):126-30. DOI: 10.1016/j.chroma.2005.03.071. View

Jia W, Shen J, Wei S, Li C, Shi J, Zhao L . Ropivacaine inhibits the malignant behavior of lung cancer cells by regulating retinoblastoma-binding protein 4. PeerJ. 2023; 11:e16471. PMC: 10688306. DOI: 10.7717/peerj.16471. View

10.

Bern S, Weinberg G . Local anesthetic toxicity and lipid resuscitation in pregnancy. Curr Opin Anaesthesiol. 2011; 24(3):262-7. DOI: 10.1097/ACO.0b013e32834654df. View

11.

Tolonen H, Andersson A, Holmboe S, Meltzer H . Health information for human biomonitoring studies. Int J Hyg Environ Health. 2022; 246:114051. DOI: 10.1016/j.ijheh.2022.114051. View

12.

Graff V, Gabutti L, Treglia G, Pascale M, Anselmi L, Cafarotti S . Perioperative costs of local or regional anesthesia versus general anesthesia in the outpatient setting: a systematic review of recent literature. Braz J Anesthesiol. 2021; 73(3):316-339. PMC: 10240220. DOI: 10.1016/j.bjane.2021.09.012. View

13.

Lamy E, Fall F, Boigne L, Gromov K, Fabresse N, Grassin-Delyle S . Validation according to European and American regulatory agencies guidelines of an LC-MS/MS method for the quantification of free and total ropivacaine in human plasma. Clin Chem Lab Med. 2019; 58(5):701-708. DOI: 10.1515/cclm-2018-1298. View

14.

Simpson D, Curran M, Oldfield V, Keating G . Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2006; 65(18):2675-717. DOI: 10.2165/00003495-200565180-00013. View

15.

Ingle R, Zeng S, Jiang H, Fang W . Current developments of bioanalytical sample preparation techniques in pharmaceuticals. J Pharm Anal. 2022; 12(4):517-529. PMC: 9463481. DOI: 10.1016/j.jpha.2022.03.001. View

16.

Kampe S, Poetter C, Buzello S, Wenchel H, Paul M, Kiencke P . Ropivacaine 0.1% with sufentanil 1 microg/mL inhibits in vitro growth of Pseudomonas aeruginosa and does not promote multiplication of Staphylococcus aureus. Anesth Analg. 2003; 97(2):409-411. DOI: 10.1213/01.ANE.0000067404.84486.7A. View

17.

Tanaka E, Nakamura T, Inomata S, Honda K . Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 834(1-2):213-6. DOI: 10.1016/j.jchromb.2006.02.034. View

18.

Kirksey M, Haskins S, Cheng J, Liu S . Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualitative Review. PLoS One. 2015; 10(9):e0137312. PMC: 4565585. DOI: 10.1371/journal.pone.0137312. View

19.

Dossou K, Chiap P, Servais A, Fillet M, Crommen J . Development and validation of a LC method for the enantiomeric purity determination of S-ropivacaine in a pharmaceutical formulation using a recently commercialized cellulose-based chiral stationary phase and polar non-aqueous mobile phase. J Pharm Biomed Anal. 2010; 54(4):687-93. DOI: 10.1016/j.jpba.2010.10.020. View

20.

Mathieu O, Hillaire-Buys D, Dadure C, Barnay F, Mathieu-Daude J, Bressolle F . Liquid chromatography-electrospray mass spectrometry determination of free and total concentrations of ropivacaine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 831(1-2):91-8. DOI: 10.1016/j.jchromb.2005.11.035. View