Research Progress of Liquid Biopsy Based on DNA Methylation in Tumor Diagnosis and Treatment

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2025 Jan 8

PMID 39766341

Authors

Yunxia Bao

Xianzhao Wang

Bingjie Zeng

Yichun Shi

Yiman Huang

Yiwen Huang

Shuang Shang

Liang Shan

Lifang Ma

Affiliations

Soon will be listed here.

Abstract

Liquid biopsy has been gradually applied to the clinical diagnosis and treatment of tumors because of its non-invasive and real-time reflection of the tumor status, as well as the convenience of sample collection, which allows the detection of primary or metastatic malignant tumors and reflects the heterogeneity of the tumors. DNA methylation, which is a type of epigenetic modification, is essential in the progression of tumors. This review introduces the common DNA methylation analysis methods and discusses their advantages and disadvantages, focusing on the new progress of DNA methylation-based liquid biopsy in tumor diagnosis and treatment.

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