Fluence Rate-dependent Kinetics of Light-triggered Liposomal Doxorubicin Assessed by Quantitative Fluorescence-based Endoscopic Probe

Overview

Journal bioRxiv

Date 2025 Jan 7

PMID 39763811

Authors

Daniel J Rohrbach

Kevin A Carter

Dandan Luo

Shuai Shao

Semra Aygun-Sunar

Jonathan F Lovell

Ulas Sunar

Affiliations

Soon will be listed here.

Abstract

Liposomal doxorubicin (Dox), a treatment option for recurrent ovarian cancer, often suffers from suboptimal biodistribution and efficacy, which might be addressed with precision drug delivery systems. Here, we introduce a catheter-based endoscopic probe designed for multispectral, quantitative monitoring of light-triggered drug release. This tool utilizes red-light photosensitive porphyrin-phospholipid (PoP), which is encapsulated in liposome bilayers to enhance targeted drug delivery. By integrating diffuse reflectance and fluorescence spectroscopy, our approach not only corrects the effects of tissue optical properties but also ensures accurate drug delivery to deep-seated tumors. Preliminary results validate the probe effectiveness in controlled settings, highlighting its potential for future clinical adaptation. This study sets the stage for in vivo applications, enabling the exploration of next-generation treatment paradigms for the management of cancer by optimizing chemotherapy administration with precision and control.

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