Tracer Study on a Paracellular Route in Experimental Hydrocephalus

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1985 Jan 1

PMID 3976360

Citations 5

Authors

Y Nakagawa

J Cervos-Navarro

J Artigas

Affiliations

Soon will be listed here.

Abstract

Considering the possibility of a paracellular pathway for edema resolution, we studied the intracerebral movement of proteins and ionic lanthanum in rats with experimental hydrocephalus. Hydrocephalus was induced by injection of kaolin suspension into the cisterna magna. After induction of hydrocephalus, horseradish peroxidase (HRP), microperoxidase (MP), or lanthanum chloride (LaCl3) were perfused into the ventricle system. HRP and MP were localized mainly in the intercellular spaces between ependymal cells, glial cells, and in perivascular spaces and were restricted by endothelial tight junctions. Ionic lanthanum (La3+), however, penetrated these tight junctions and moved between the blood and CSF cavities by paracellular pathways. These findings indicate that in obstructive hydrocephalus, the tight junctions may constitute part of a paracellular pathway for the transendothelial movement of small solutes, although they prevent the movement of larger molecules.

Citing Articles

Magnetic resonance imaging indicators of blood-brain barrier and brain water changes in young rats with kaolin-induced hydrocephalus.

Del Bigio M, Slobodian I, Schellenberg A, Buist R, Kemp-Buors T Fluids Barriers CNS. 2011; 8:22.

PMID: 21834998 PMC: 3162928. DOI: 10.1186/2045-8118-8-22.

Neuropathological changes caused by hydrocephalus.

Del Bigio M Acta Neuropathol. 1993; 85(6):573-85.

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Cerebrospinal fluid absorption in the rabbit. Optic pathways.

Gomez D, Manzo R, Fenstermacher J, POTTS D Graefes Arch Clin Exp Ophthalmol. 1988; 226(1):1-7.

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Quantitative morphology of human glioblastoma multiforme microvessels: structural basis of blood-brain barrier defect.

Coomber B, Stewart P, Hayakawa K, Farrell C, Del Maestro R J Neurooncol. 1987; 5(4):299-307.

PMID: 2831312 DOI: 10.1007/BF00148386.

Blood-brain barrier permeability to micromolecules and edema formation in the early phase of incomplete continuous ischemia.

Sampaolo S, Nakagawa Y, Iannotti F, Cervos-Navarro J, Bonavita V Acta Neuropathol. 1991; 82(2):107-11.

PMID: 1927266 DOI: 10.1007/BF00293952.

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