Targeting Mitochondrial Function As a Potential Therapeutic Approach for Allergic Asthma

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2025 Jan 6

PMID 39762562

Authors

Daichi Chen

Wanhua Wu

Jianing Li

Xueqin Huang

Su Chen

Tingting Zheng

Gonghua Huang

Suidong Ouyang

Affiliations

Soon will be listed here.

Abstract

Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, excessive mucus secretion, and airway remodeling, with increasing mortality and incidence globally. The pathogenesis of allergic asthma is influenced by various factors including genetics, environment, and immune responses, making it complex and diverse. Recent studies have found that various cellular functions of mitochondria such as calcium regulation, adenosine triphosphate production, changes in redox potential, and free radical scavenging, are involved in regulating the pathogenesis of asthma. This review explores the involvement of mitochondrial functional changes in the pathogenesis of asthma, and investigate the potential of targeting cellular mitochondria as a therapeutic approach for asthma. Those insights can provide a novel theoretical foundations and treatment strategies for understanding and preventing asthma.

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