Enhanced Skin Penetration of Curcumin by a Nanoemulsion-embedded Oligopeptide Hydrogel for Psoriasis Topical Therapy

Overview

Journal RSC Med Chem

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2025 Jan 6

PMID 39760102

Authors

Kehan Chen

Hui Yang

Guo Xu

Yunhan Hu

Xue Tian

Song Qin

Tianyue Jiang

Affiliations

Soon will be listed here.

Abstract

Topical delivery of therapeutics on the skin can effectively alleviate skin symptoms of psoriasis and reduce systemic toxicity. However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact. Here, we reported an oligopeptide hydrogel that encapsulates cell-penetrating-peptide (CPP)-decorated curcumin-loaded nanoemulsions (Cur-CNEs) to enhance the skin penetration of curcumin for topical treatment of psoriasis. After being applied to the skin of psoriatic mice, the Cur-CNE embedded oligopeptide hydrogel (Cur-CNEs/Gel) provided a prolonged residue time of Cur-CNEs on the skin lesion. The fluidic and elastic properties of the nanoemulsions enabled them to effectively pass through the interstitial spaces of the stratum corneum, while the CPP decoration further enhanced skin penetration and cellular uptake of Cur-CNEs. The Cur-CNEs/Gel exhibits effective alleviation of the symptoms of psoriasis in mice and provides a promising strategy for topical treatment of psoriasis.

References

Griffiths C, Barker J . Pathogenesis and clinical features of psoriasis. Lancet. 2007; 370(9583):263-271. DOI: 10.1016/S0140-6736(07)61128-3. View

Griffiths C, van der Walt J, Ashcroft D, Flohr C, Naldi L, Nijsten T . The global state of psoriasis disease epidemiology: a workshop report. Br J Dermatol. 2017; 177(1):e4-e7. PMC: 5600082. DOI: 10.1111/bjd.15610. View

Xu J, Jiang M, Sun H, He B . An organic solvent-stable protease from organic solvent-tolerant Bacillus cereus WQ9-2: purification, biochemical properties, and potential application in peptide synthesis. Bioresour Technol. 2010; 101(20):7991-4. DOI: 10.1016/j.biortech.2010.05.055. View

Singh Y, Meher J, Raval K, Khan F, Chaurasia M, Jain N . Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release. 2017; 252:28-49. DOI: 10.1016/j.jconrel.2017.03.008. View

Kang N, Kim M, Sohn S, Kim K, Park J, Lee S . Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Biomaterials. 2018; 182:245-258. DOI: 10.1016/j.biomaterials.2018.08.030. View

Elzayat A, Adam-Cervera I, Alvarez-Bermudez O, Munoz-Espi R . Nanoemulsions for synthesis of biomedical nanocarriers. Colloids Surf B Biointerfaces. 2021; 203:111764. DOI: 10.1016/j.colsurfb.2021.111764. View

Lowes M, Suarez-Farinas M, Krueger J . Immunology of psoriasis. Annu Rev Immunol. 2014; 32:227-55. PMC: 4229247. DOI: 10.1146/annurev-immunol-032713-120225. View

Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B . Transdermal permeation of Kaempferia parviflora methoxyflavones from isopropyl myristate-based vehicles. AAPS PharmSciTech. 2014; 15(4):947-55. PMC: 4113614. DOI: 10.1208/s12249-014-0122-y. View

Shakeel F, Shafiq S, Haq N, Alanazi F, Alsarra I . Nanoemulsions as potential vehicles for transdermal and dermal delivery of hydrophobic compounds: an overview. Expert Opin Drug Deliv. 2012; 9(8):953-74. DOI: 10.1517/17425247.2012.696605. View

10.

Ghosh V, Mukherjee A, Chandrasekaran N . Ultrasonic emulsification of food-grade nanoemulsion formulation and evaluation of its bactericidal activity. Ultrason Sonochem. 2012; 20(1):338-44. DOI: 10.1016/j.ultsonch.2012.08.010. View

11.

de Gannes G, Ghoreishi M, Pope J, Russell A, Bell D, Adams S . Psoriasis and pustular dermatitis triggered by TNF-{alpha} inhibitors in patients with rheumatologic conditions. Arch Dermatol. 2007; 143(2):223-31. DOI: 10.1001/archderm.143.2.223. View

12.

Jiang T, Shen S, Wang T, Li M, He B, Mo R . A Substrate-Selective Enzyme-Catalysis Assembly Strategy for Oligopeptide Hydrogel-Assisted Combinatorial Protein Delivery. Nano Lett. 2017; 17(12):7447-7454. DOI: 10.1021/acs.nanolett.7b03371. View

13.

Nikolic I, Lunter D, Randjelovic D, Zugic A, Tadic V, Markovic B . Curcumin-loaded low-energy nanoemulsions as a prototype of multifunctional vehicles for different administration routes: Physicochemical and in vitro peculiarities important for dermal application. Int J Pharm. 2018; 550(1-2):333-346. DOI: 10.1016/j.ijpharm.2018.08.060. View

14.

Hashemnejad S, Badruddoza A, Zarket B, Ricardo Castaneda C, Doyle P . Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process. Nat Commun. 2019; 10(1):2749. PMC: 6588569. DOI: 10.1038/s41467-019-10749-1. View

15.

Chiricozzi A, Guttman-Yassky E, Suarez-Farinas M, Nograles K, Tian S, Cardinale I . Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J Invest Dermatol. 2010; 131(3):677-87. DOI: 10.1038/jid.2010.340. View

16.

Zhang L, Ren X, Zhou P, Wu F, Liu L, Hai Z . Sequential self-assembly and disassembly of curcumin hydrogel effectively alleviates inflammatory bowel disease. Biomater Sci. 2022; 10(22):6517-6524. DOI: 10.1039/d2bm01120d. View

17.

Boehncke W, Wortmann S, Kaufmann R, Mielke V, Sterry W . A subset of macrophages located along the basement membrane ("lining cells") is a characteristic histopathological feature of psoriasis. Am J Dermatopathol. 1995; 17(2):139-44. DOI: 10.1097/00000372-199504000-00005. View

18.

Khurana S, Jain N, Bedi P . Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation. Life Sci. 2013; 92(6-7):383-92. DOI: 10.1016/j.lfs.2013.01.005. View

19.

Rai V, Mishra N, Yadav K, Yadav N . Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications. J Control Release. 2017; 270:203-225. DOI: 10.1016/j.jconrel.2017.11.049. View

20.

Sala M, Diab R, Elaissari A, Fessi H . Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications. Int J Pharm. 2017; 535(1-2):1-17. DOI: 10.1016/j.ijpharm.2017.10.046. View