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Herpes Simplex Pneumonitis Presenting As Acute Respiratory Distress Syndrome and Septic Shock

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Journal Cureus
Date 2025 Jan 6
PMID 39759712
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Abstract

We present a case report of a 72-year-old female with a history of stage III rectal adenocarcinoma undergoing chemotherapy who developed neutropenic sepsis and acute respiratory failure. The patient was admitted to the intensive care unit (ICU) due to worsening respiratory status and was subsequently diagnosed with disseminated herpes simplex virus (HSV) infection including acute respiratory distress syndrome (ARDS). This case highlights the challenges in diagnosing and managing HSV infection in critically ill patients and emphasizes the importance of early recognition and appropriate treatment in improving patient outcomes. This case underscores the significance of considering viral etiologies, such as HSV, in patients with unexplained respiratory symptoms presenting as ARDS.

References
1.
Berrington W, Jerome K, Cook L, Wald A, Corey L, Casper C . Clinical correlates of herpes simplex virus viremia among hospitalized adults. Clin Infect Dis. 2009; 49(9):1295-301. PMC: 2803101. DOI: 10.1086/606053. View

2.
Singh A, Preiksaitis J, Ferenczy A, Romanowski B . The laboratory diagnosis of herpes simplex virus infections. Can J Infect Dis Med Microbiol. 2007; 16(2):92-8. PMC: 2095011. DOI: 10.1155/2005/318294. View

3.
Simoons-Smit A, Kraan E, Beishuizen A, Strack van Schijndel R, Vandenbroucke-Grauls C . Herpes simplex virus type 1 and respiratory disease in critically-ill patients: Real pathogen or innocent bystander?. Clin Microbiol Infect. 2006; 12(11):1050-9. DOI: 10.1111/j.1469-0691.2006.01475.x. View

4.
Lepiller Q, Sueur C, Solis M, Barth H, Glady L, Lefebvre F . Clinical relevance of herpes simplex virus viremia in Intensive Care Unit patients. J Infect. 2015; 71(1):93-100. DOI: 10.1016/j.jinf.2015.02.013. View

5.
Traen S, Bochanen N, Ieven M, Schepens T, Bruynseels P, Verbrugghe W . Is acyclovir effective among critically ill patients with herpes simplex in the respiratory tract?. J Clin Virol. 2014; 60(3):215-21. DOI: 10.1016/j.jcv.2014.04.010. View