The Modulation of Immune Cell Death in Connection to MicroRNAs and Natural Products

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2025 Jan 6

PMID 39759512

Authors

Ya-Ting Chuang

Ching-Yu Yen

Jen-Yang Tang

Fang-Rong Chang

Yi-Hong Tsai

Kuo-Chuan Wu

Tsu-Ming Chien

Hsueh-Wei Chang

Affiliations

Soon will be listed here.

Abstract

Immunogenic cell death (ICD) spatiotemporally regulates damage-associated molecular patterns (DAMPs) derived from dying cancer cells to signal the immune response. Intriguingly, these DAMPs and cytokines also induce cellular responses in non-immune cells, particularly cancer cells. Several ICD-modulating natural products and miRNAs have been reported to regulate the DAMP, cytokine, and cell death responses, but they lack systemic organization and connection. This review summarizes the impacts of natural products and miRNAs on the DAMP and cytokine responses and cancer cell death responses (apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis). We establish the rationale that ICD inducers of natural products have modulating effects on miRNAs, targeting DAMPs and cytokines for immune and cancer cell death responses. In conclusion, DAMP, cytokine, and cell death responses are intricately linked in cancer cells, and they are influenced by ICD-modulating natural products and miRNAs.

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