Impact of Thrombocytopenia on Failure of Endoscopic Variceal Treatment in Cirrhotic Patients with Acute Variceal Bleeding

Overview

Journal Therap Adv Gastroenterol

Publisher Sage Publications

Specialty Gastroenterology

Date 2025 Jan 6

PMID 39758964

Authors

Yan He

Fernando Gomes Romeiro

Mingyu Sun

Fanpu Ji

Qiang Zhu

Yingli He

Dapeng Ma

Shanshan Yuan

Xiaofeng Liu

Cyriac Abby Philips

Metin Basaranoglu

Nahum Mendez-Sanchez

Kanokwan Pinyopornpanish

Yiling Li

Yunhai Wu

Ling Yang

Lichun Shao

Andrea Mancuso

Yu Chen

Frank Tacke

Su Lin

Lei Liu

Bimin Li

Xingshun Qi

Affiliations

Soon will be listed here.

Abstract

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

Objectives: We investigated the association between thrombocytopenia and the failure of EVT in cirrhotic patients with AVB.

Design: International multicenter, retrospective study.

Methods: Overall, 2467 cirrhotic patients with acute gastrointestinal bleeding who were enrolled into an international multicenter study between September 30, 2020 and June 30, 2023 were retrospectively screened. Thrombocytopenia was defined as platelet count below 150 × 10/L and further classified as mild (100 × 10/L-150 × 10/L), moderate (50 × 10/L-100 × 10/L), and severe (<50 × 10/L). A 1:1 propensity score matching (PSM) analysis was performed. Five-day failure to control bleeding was evaluated.

Results: Overall, 1079 patients were included, of whom 923 (85.5%) had thrombocytopenia, including mild ( = 241), moderate ( = 445), and severe ( = 237) thrombocytopenia. PSM analysis demonstrated that the rate of 5-day failure to control bleeding was not significantly different between patients with and without thrombocytopenia (mild: (12/153) 7.8% vs (7/153) 4.6%, = 0.236; moderate: (9/155) 5.8% vs (7/155) 4.5%, = 0.608; or severe: (5/132) 3.8% vs (7/132) 5.3%, = 0.555).

Conclusion: Thrombocytopenia may not influence the efficacy of EVT in cirrhotic patients with AVB.

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