Meniran ( L.) Embedded Zeolitic Imidazolate Framework (ZIF-8) Nanoparticle for Cancer Chemotherapy: Supported Molecular Docking Analysis

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2025 Jan 6

PMID 39758894

Authors

Fasih Bintang Ilhami

Sari Edi Cahyaningrum

Andika Pramudya Wardana

Noto Susanto Gultom

Hasan Subekti

Astrid Rahmawati

Sapti Puspitarini

Affiliations

Soon will be listed here.

Abstract

Cancer is among the leading causes of mortality worldwide. Natural bioactive compounds like Meniran ( L.) have been the focus of extensive research due to their potent anticancer properties. Nevertheless, drug delivery strategies may be necessary to encapsulate bioactive compounds, thereby reducing their toxicity and enhancing their stability. Herein, we successfully synthesized Meniran extract incorporated zeolitic imidazolate framework (ZIF-8) nanoparticles for anticancer therapy. Meniran-incorporated ZIF-8 nanoparticles possess unique advantages including well-distributed nanoparticles with rhombic dodecahedrons and excellent pH-responsiveness. analysis showed that Meniran-incorporated ZIF-8 nanoparticles have anticancer activity towards HeLa cells. Interestingly, computational simulations offer valuable insights into the molecular-level interaction mechanisms between ZIF-8 and specific proteins under cancer cells. As far as we are aware, this is the first report of natural bioactive compounds derived from Meniran encapsulated into nanoparticles as a drug delivery system, marking a significant advancement in the development of novel biomaterials for cancer treatment.

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