The Influence of Study Quality, Age, and Geographic Factors on Pcos Prevalence - A Systematic Review and Meta-Analysis

Background: Polycystic ovary syndrome (PCOS) is a highly prevalent disorder with substantial burden, yet global epidemiological data remains limited.

Objectives: To estimate the PCOS prevalence globally.

Materials And Methods: We systematically searched PubMed and Embase for PCOS studies in unselected populations through February 2024.

Results: Our study included 88 studies (n=561,287 women) from 7,144 records. The highest PCOS prevalence was identified by Rotterdam criteria, followed by Androgen Excess and PCOS Society (AE-PCOS), and National Institutes of Health (NIH). High-quality studies indicated prevalences of 10.89%, 10.61%, and 6.63% using Rotterdam, AE-PCOS, and NIH, respectively. Considering only high-quality studies, as assessed using a newly developed PCOS Epidemiology and Phenotype (PEP) tool, revealed no significant regional disparities using either NIH (ranging from 5.72% in Eastern Mediterranean Region [EMR] to 6.90% in Western Pacific Region [WPR]) or Rotterdam (ranging from 11.15% in South-East Asia to 9.12% in EMR). For AE-PCOS, sufficient data was available only for WPR region (6.9%). No studies were available in the African Region. A higher PCOS prevalence was observed in adults than adolescents using NIH (8.52% vs. 4.44%; p= 0.01), although the difference diminished when considering only high-quality studies (7.25% vs. 4.44%; p= 0.053). Limited data restricted age-group comparisons using Rotterdam and AE-PCOS.

Conclusions: This systematic review and meta-analysis reveals a trend towards regional variations and age differences across diagnostic criteria. The study results suggest considering study quality using instruments tailored for epidemiological studies in PCOS, such as the PEP tool, when carrying out these types of meta-analyses.