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Genotoxicity of Formaldehyde in Cultured Human Bronchial Fibroblasts

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Journal Science
Specialty Science
Date 1985 Apr 5
PMID 3975633
Citations 15
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Abstract

Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.

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