Photoredox Radical/polar Crossover Enables Carbo-heterofunctionalization of Alkenes: Facile Access to 1,3-difunctionalized Nitro Compounds

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2025 Jan 3

PMID 39749586

Authors

Subrata Patra

Vasiliki Valsamidou

Bhargav N Nandasana

Dmitry Katayev

Affiliations

Soon will be listed here.

Abstract

Herein, we present an efficient and practical method for multicomponent carbo-heterofunctionalization of alkenes radical-polar crossover photoredox catalysis. Employing geminal bromonitroalkanes as redox-active reagents with a wide range of O-centered nucleophiles allows rapid access to various 1,3-difunctionalized nitro compounds, including β-nitro ketones, 1,3-nitro alcohols, 1,3-nitro ethers as well as cyclic molecules.

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