Gamma Delta T Cells in Cancer Therapy: from Tumor Recognition to Novel Treatments

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2025 Jan 3

PMID 39748921

Authors

Xinyu Luo

Yufan Lv

Jinsai Yang

Rou Long

Jieya Qiu

Yuqi Deng

Guiyang Tang

Chaohui Zhang

Jiale Li

Jianhong Zuo

Affiliations

Soon will be listed here.

Abstract

Traditional immunotherapies mainly focus on αβ T cell-based strategies, which depend on MHC-mediated antigen recognition. However, this approach poses significant challenges in treating recurrent tumors, as immune escape mechanisms are widespread. γδ T cells, with their ability for MHC-independent antigen presentation, offer a promising alternative that could potentially overcome limitations observed in traditional immunotherapies. These cells play a role in tumor immune surveillance through a unique mechanism of antigen recognition and synergistic interactions with other immune effector cells. In this review, we will discuss the biological properties of the Vδ1 and Vδ2 T subsets of γδ T cells, their immunomodulatory role within the tumor microenvironment, and the most recent clinical advances in γδ T cell-based related immunotherapies, including cell engaging strategies and adoptive cell therapy.

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