Impact of Lumbar Cerebrospinal Fluid Drainage to Control Intracranial Hypertension in Patients with Severe Traumatic Brain Injury: a Retrospective Monocentric Cohort

Overview

Journal Crit Care

Specialty Critical Care

Date 2025 Jan 3

PMID 39748237

Authors

Geoffrey Dagod

Marlene Laurens

Jean-Paul Roustan

Pauline Deras

Elie Courvalin

Mehdi Girard

Hugues Weber

Xavier Capdevila

Jonathan Charbit

Affiliations

Soon will be listed here.

Abstract

Background: External lumbar drainage (ELD) of cerebrospinal fluid may help control intracranial pressure following a traumatic brain injury. We aimed to assess the efficacy and safety of ELD in post-traumatic intracranial hypertension (IH).

Methods: This retrospective monocentric cohort study was conducted in the trauma critical care unit of the regional Level-I trauma centre between January 2012 and December 2022. All traumatic brain injury patients with IH (≥ 22 mmHg despite optimal sedation) were included. Data collection focused on the duration and management of IH, complications related to ELD, and outcomes (6-month Glasgow Outcome Scale [GOS]). The influence of ELD on the duration of IH was assessed using a multivariable Cox regression analysis, while its impact on the 6-month GOS ("unfavourable outcome" GOS 1-3, "good outcome" GOS 4-5) was evaluated using a multivariable logistic regression analysis.

Results: Ninety patients (mean age 37 [SD, 16], injury severity score [ISS] 29 [IQR, 24-34]) were analyzed during the study period. Of these, 50 (56%) benefited from an ELD during their hospitalization (ELD group). The IH duration was significantly reduced in the ELD group (hazard ratio [HR] 1.74 [95% confidence interval (CI) 1.05-2.87; p = 0.03]). One patient (2%) experienced a cerebral herniation following ELD placement, and two others (4%) developed device-associated meningitis. The ELD group was significantly associated with a lower likelihood of an unfavourable outcome (OR 0.32 [95% CI 0.13-0.77]; p = 0.011) compared to the no ELD group.

Conclusion: ELD appears in our cohort to be a safe and effective strategy to control post-traumatic IH, with an acceptable benefit-risk ratio. Our analysis even suggests a potential outcome improvement in patients treated by ELD compared with those having no cerebrospinal fluid drainage.

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