An Mpox Quadrivalent MRNA Vaccine Elicits Sustained and Protective Immunity in Mice Against Lethal Vaccinia Virus Challenge

Overview

Journal Emerg Microbes Infect

Specialty Infectious Diseases

Date 2025 Jan 2

PMID 39745170

Authors

Entao Li

Qiyuan Yang

Wenyu Xie

Qizan Gong

Xiaoping Guo

Jinge Zhou

Jiachen Zhang

Xia Chuai

Yucai Wang

Sandra Chiu

Affiliations

Soon will be listed here.

Abstract

Assessing the long-term efficacy of MPXV vaccine candidates is crucial for the global response to the ongoing mpox epidemic. Built upon our previous study of the mpox quadrivalent mRNA vaccine, herein we reported that MPXV-1103 could elicit sustained humoral and cellular immunity in mice, including the induction of MPXV A35/B6/A29/M1-specific IgG antibodies, VACV neutralizing antibodies and activated cytotoxic CD8T cells, which provides 100% protection against lethal VACV challenge even at 280 days after the first vaccination. Our results provide critical insights for orthopoxvirus vaccine development.

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