Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics

Overview

Journal J Cancer

Specialty Oncology

Date 2025 Jan 2

PMID 39744484

Authors

Wanrou Jiang

Yongjun Wu

Xiuyun He

Ling Jiang

Wanyi Zhang

Wenjuan Zheng

Min Hu

Chaofu Zhu

Affiliations

Soon will be listed here.

Abstract

Chemotherapy-induced diarrhea (CID) is a common and harmful side effect of chemotherapy, greatly impacting patients' quality of life and potentially compromising their chances of survival. Disruption of the balance in intestinal microbiota and compromised integrity of the intestinal barrier are key factors contributing to CID caused by mucositis. This paper investigated the mechanism through which intestinal microbiota activate Toll-like receptors and STING pathways to mediate intestinal mucosal inflammation resulting from immune responses in the gut, uncovering a novel mechanism of intestinal microbiota in chemotherapy-induced diarrhea, and suggesting innovative approaches for the prevention and management of CID.

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