Skeletal Interoception and Prospective Application in Biomaterials for Bone Regeneration

Overview

Journal Bone Res

Specialties Endocrinology
Orthopedics

Date 2025 Jan 1

PMID 39743568

Authors

Long Bai

Jilong Li

Guangfeng Li

Dongyang Zhou

Jiacan Su

Changsheng Liu

Affiliations

Soon will be listed here.

Abstract

Accumulating research has shed light on the significance of skeletal interoception, in maintaining physiological and metabolic homeostasis related to bone health. This review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis, delving into the complex interplay between the nervous system and skeletal system. One key focus of the review is the role of various factors such as prostaglandin E2 (PGE2) in skeletal health via skeletal interoception. It explores how nerves innervating the bone tissue communicate with the central nervous system to regulate bone remodeling, a process critical for maintaining bone strength and integrity. Additionally, the review highlights the advancements in biomaterials designed to utilize skeletal interoception for enhancing bone regeneration and treatment of bone disorders. These biomaterials, tailored to interact with the body's interoceptive pathways, are positioned at the forefront of innovative treatments for conditions like osteoporosis and fractures. They represent a convergence of bioengineering, neuroscience, and orthopedics, aiming to create more efficient and targeted therapies for bone-related disorders. In conclusion, the review underscores the importance of skeletal interoception in physiological regulation and its potential in developing more effective therapies for bone regeneration. It emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.

References

Lv X, Gao F, Cao X . Skeletal interoception in bone homeostasis and pain. Cell Metab. 2022; 34(12):1914-1931. PMC: 9742337. DOI: 10.1016/j.cmet.2022.09.025. View

Rodriguez F, Scheinker D, Harrington R . Promise and Perils of Big Data and Artificial Intelligence in Clinical Medicine and Biomedical Research. Circ Res. 2018; 123(12):1282-1284. DOI: 10.1161/CIRCRESAHA.118.314119. View

Tank A, Wong D . Peripheral and central effects of circulating catecholamines. Compr Physiol. 2015; 5(1):1-15. DOI: 10.1002/cphy.c140007. View

Niedermair T, Schirner S, Seebroker R, Straub R, Grassel S . Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts. Sci Rep. 2018; 8(1):9199. PMC: 6003941. DOI: 10.1038/s41598-018-27432-y. View

Fu S, Mei G, Wang Z, Zou Z, Liu S, Pei G . Neuropeptide substance P improves osteoblastic and angiogenic differentiation capacity of bone marrow stem cells in vitro. Biomed Res Int. 2014; 2014:596023. PMC: 4090442. DOI: 10.1155/2014/596023. View

Masuda T, Taniguchi M . Contribution of semaphorins to the formation of the peripheral nervous system in higher vertebrates. Cell Adh Migr. 2016; 10(6):593-603. PMC: 5160040. DOI: 10.1080/19336918.2016.1243644. View

Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H . Bone-protective Functions of Netrin 1 Protein. J Biol Chem. 2016; 291(46):23854-23868. PMC: 5104911. DOI: 10.1074/jbc.M116.738518. View

Jing X, Xu C, Su W, Ding Q, Ye B, Su Y . Photosensitive and Conductive Hydrogel Induced Innerved Bone Regeneration for Infected Bone Defect Repair. Adv Healthc Mater. 2022; 12(3):e2201349. DOI: 10.1002/adhm.202201349. View

Moody T, Nuche-Berenguer B, Jensen R . Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer. Curr Opin Endocrinol Diabetes Obes. 2015; 23(1):38-47. PMC: 4844466. DOI: 10.1097/MED.0000000000000218. View

10.

Chen P, Cescon M, Zuccolotto G, Nobbio L, Colombelli C, Filaferro M . Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization. Acta Neuropathol. 2014; 129(1):97-113. DOI: 10.1007/s00401-014-1369-9. View

11.

Chen J, Liu W, Zhao J, Sun C, Chen J, Hu K . Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits. Biotechnol Lett. 2016; 39(3):465-472. DOI: 10.1007/s10529-016-2263-4. View

12.

Carr L, Parkinson D, Dun X . Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system. PLoS One. 2017; 12(2):e0172736. PMC: 5325304. DOI: 10.1371/journal.pone.0172736. View

13.

Tomlinson R, Li Z, Zhang Q, Goh B, Li Z, Thorek D . NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone. Cell Rep. 2016; 16(10):2723-2735. PMC: 5014649. DOI: 10.1016/j.celrep.2016.08.002. View

14.

Walker L, Preston M, Magnay J, Thomas P, El Haj A . Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture. Bone. 2001; 28(6):603-8. DOI: 10.1016/s8756-3282(01)00427-6. View

15.

Yuan Z, Wan Z, Wei P, Lu X, Mao J, Cai Q . Dual-Controlled Release of Icariin/Mg from Biodegradable Microspheres and Their Synergistic Upregulation Effect on Bone Regeneration. Adv Healthc Mater. 2020; 9(11):e2000211. DOI: 10.1002/adhm.202000211. View

16.

Bryson T, Harding P . Prostaglandin E2 EP receptors in cardiovascular disease: An update. Biochem Pharmacol. 2021; 195:114858. DOI: 10.1016/j.bcp.2021.114858. View

17.

Li Z, Meyers C, Chang L, Lee S, Li Z, Tomlinson R . Fracture repair requires TrkA signaling by skeletal sensory nerves. J Clin Invest. 2019; 129(12):5137-5150. PMC: 6877307. DOI: 10.1172/JCI128428. View

18.

Wang F, Gu Z, Yin Z, Zhang W, Bai L, Su J . Cell unit-inspired natural nano-based biomaterials as versatile building blocks for bone/cartilage regeneration. J Nanobiotechnology. 2023; 21(1):293. PMC: 10463900. DOI: 10.1186/s12951-023-02003-0. View

19.

Kandalam S, Sindji L, Delcroix G, Violet F, Garric X, Andre E . Pharmacologically active microcarriers delivering BDNF within a hydrogel: Novel strategy for human bone marrow-derived stem cells neural/neuronal differentiation guidance and therapeutic secretome enhancement. Acta Biomater. 2016; 49:167-180. DOI: 10.1016/j.actbio.2016.11.030. View

20.

Zhang Z, Hao Z, Xian C, Fang Y, Cheng B, Wu J . Neuro-bone tissue engineering: Multiple potential translational strategies between nerve and bone. Acta Biomater. 2022; 153:1-12. DOI: 10.1016/j.actbio.2022.09.023. View