Epigenetics As the Molecular Substrate of Multimodal Lifestyle Approaches for Patients with Persistent Pain

Overview

Journal Braz J Phys Ther

Specialty Rehabilitation Medicine

Date 2025 Jan 1

PMID 39742735

Authors

Andrea Polli

Jo Nijs

Bernard Thienpont

Affiliations

Soon will be listed here.

References

Nijs J, Lahousse A, Malfliet A . A paradigm shift from a tissue- and disease-based approach towards multimodal lifestyle interventions for chronic pain: 5 steps to guide clinical reasoning. Braz J Phys Ther. 2023; 27(5):100556. PMC: 10682524. DOI: 10.1016/j.bjpt.2023.100556. View

Johnstone S, Gladyshev V, Aryee M, Bernstein B . Epigenetic clocks, aging, and cancer. Science. 2022; 378(6626):1276-1277. DOI: 10.1126/science.abn4009. View

Xiong H, Wyns A, Van Campenhout J, Hendrix J, de Bruyne E, Godderis L . Epigenetic Landscapes of Pain: DNA Methylation Dynamics in Chronic Pain. Int J Mol Sci. 2024; 25(15). PMC: 11312850. DOI: 10.3390/ijms25158324. View

Fiorito G, Caini S, Palli D, Bendinelli B, Saieva C, Ermini I . DNA methylation-based biomarkers of aging were slowed down in a two-year diet and physical activity intervention trial: the DAMA study. Aging Cell. 2021; 20(10):e13439. PMC: 8520727. DOI: 10.1111/acel.13439. View

Cheng Y, Gadd D, Gieger C, Monterrubio-Gomez K, Zhang Y, Berta I . Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes. Nat Aging. 2023; 3(4):450-458. DOI: 10.1038/s43587-023-00391-4. View

Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner J, Pariante C . Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci. 2012; 16(1):33-41. PMC: 4136922. DOI: 10.1038/nn.3275. View

Roose E, Nijs J, Moseley G . Striving for better outcomes of treating chronic pain: integrating behavioural change strategies before, during, and after modern pain science education. Braz J Phys Ther. 2023; 27(6):100578. PMC: 10727936. DOI: 10.1016/j.bjpt.2023.100578. View

Nijs J, Mostaqim K, Oostendorp R . Exercise therapy and physical activity in the paradigm shift from a tissue- and disease-based pain management approach towards multimodal lifestyle interventions for chronic pain. Braz J Phys Ther. 2024; 28(4):101101. PMC: 11345498. DOI: 10.1016/j.bjpt.2024.101101. View

Nijs J, Mairesse O, Tang N . The importance of sleep in the paradigm shift from a tissue- and disease-based pain management approach towards multimodal lifestyle interventions for chronic pain. Braz J Phys Ther. 2024; 28(1):100594. PMC: 10877106. DOI: 10.1016/j.bjpt.2024.100594. View

10.

Elma O, Nijs J, Malfliet A . The importance of nutritional factors on the road toward multimodal lifestyle interventions for persistent pain. Braz J Phys Ther. 2024; 28(5):101119. PMC: 11406025. DOI: 10.1016/j.bjpt.2024.101119. View

11.

Galkin F, Kovalchuk O, Koldasbayeva D, Zhavoronkov A, Bischof E . Stress, diet, exercise: Common environmental factors and their impact on epigenetic age. Ageing Res Rev. 2023; 88:101956. DOI: 10.1016/j.arr.2023.101956. View

12.

Kanherkar R, Bhatia-Dey N, Csoka A . Epigenetics across the human lifespan. Front Cell Dev Biol. 2014; 2:49. PMC: 4207041. DOI: 10.3389/fcell.2014.00049. View

13.

Tamargo J, Strath L, Cruz-Almeida Y . High-Impact Pain Is Associated With Epigenetic Aging Among Middle-Aged and Older Adults: Findings From the Health and Retirement Study. J Gerontol A Biol Sci Med Sci. 2024; 79(8). PMC: 11226994. DOI: 10.1093/gerona/glae149. View

14.

Horvath S, Raj K . DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018; 19(6):371-384. DOI: 10.1038/s41576-018-0004-3. View

15.

Nijs J, Wyns A, Hendrix J . The importance of stress in the paradigm shift from a tissue- and disease-based pain management approach towards multimodal lifestyle interventions for chronic pain. Braz J Phys Ther. 2024; 28(2):101061. PMC: 11015500. DOI: 10.1016/j.bjpt.2024.101061. View

16.

Jylhava J, Pedersen N, Hagg S . Biological Age Predictors. EBioMedicine. 2017; 21:29-36. PMC: 5514388. DOI: 10.1016/j.ebiom.2017.03.046. View

17.

Burke N, Finn D, McGuire B, Roche M . Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms. J Neurosci Res. 2016; 95(6):1257-1270. DOI: 10.1002/jnr.23802. View

18.

Macfarlane G, Barnish M, Jones G . Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017; 76(11):1815-1822. DOI: 10.1136/annrheumdis-2017-211476. View

19.

Joehanes R, Just A, Marioni R, Pilling L, Reynolds L, Mandaviya P . Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016; 9(5):436-447. PMC: 5267325. DOI: 10.1161/CIRCGENETICS.116.001506. View

20.

Nijs J, Malfliet A, Roose E, Lahousse A, Van Bogaert W, Johansson E . Personalized Multimodal Lifestyle Intervention as the Best-Evidenced Treatment for Chronic Pain: State-of-the-Art Clinical Perspective. J Clin Med. 2024; 13(3). PMC: 10855981. DOI: 10.3390/jcm13030644. View