Radiomics Based Machine Learning Models for Classification of Prostate Cancer Grade Groups from Multi Parametric MRI Images

Overview

Journal J Med Signals Sens

Specialty Biomedical Engineering

Date 2025 Jan 1

PMID 39741789

Authors

Fatemeh Zandie

Mohammad Salehi

Asghar Maziar

Mohammad Reza Bayatiani

Reza Paydar

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to investigate the performance of multiparametric magnetic resonance imaging (mpMRI) radiomic feature-based machine learning (ML) models in classifying the Gleason grade group (GG) of prostate cancer.

Methods: In this retrospective study, a total of 203 patients with histopathologically confirmed prostate cancer who underwent mpMRI before prostate biopsy were included. After manual segmentation, radiomic features (RFs) were extracted from T2-weighted, apparent diffusion coefficient, and high b-value diffusion-weighted magnetic resonance imaging (DWMRI). Patients were split into training sets and testing sets according to a ratio of 8:2. A pipeline considering combinations of two feature selection (FS) methods and six ML classifiers was developed and evaluated. The performance of models was assessed using the accuracy, sensitivity, precision, F1-measure, and the area under curve (AUC).

Results: On high b-value DWMRI-derived features, a combination of FS method recursive feature elimination (RFE) and classifier random forest achieved the highest performance for classification of prostate cancer into five GGs, with 97.0% accuracy, 98.0% sensitivity, 98.0% precision, and 97.0% F1-measure. The method also achieved an average AUC for GG of 98%.

Conclusion: Preoperative mpMRI radiomic analysis based on ML, as a noninvasive approach, showed good performance for classification of prostate cancer into five GGs.

Advances In Knowledge: Herein, radiomic models based on preoperative mpMRI and ML were developed to classify prostate cancer into 5 GGs. Our study provides evidence that analysis of quantitative RFs extracted from high b-value DWMRI images based on a combination of FS method RFE and classifier random forest can be applied for multiclass grading of prostate cancer with an accuracy of 97.0%.

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