Effect of Selective Dorsal Rhizotomy on Bladder Dysfunction in Children with Spastic Cerebral Palsy

Overview

Journal Sci Rep

Specialty Science

Date 2024 Dec 31

PMID 39738149

Authors

Wenbin Jiang

Junlu Wang

Pierre A Robe

Min Wei

Sen Li

Rui Wang

Qijia Zhan

Bo Xiao

Affiliations

Soon will be listed here.

Abstract

This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative LUTS improvement and intraoperative electrophysiological findings. Prospective data were collected from a consecutive cohort of 247 children with SCP who underwent SDR and were retrospectively analyzed. Pre- and post-operative assessments included muscle tone, motor function, LUTS and intraoperative electrophysiology data were analyzed. Preoperatively, 94 patients (38.1%) had LUTS, and the severity of LUTS negatively correlated with motor function (R=-0.32, P < 0.0001). After SDR, muscle tone decreased, motor function improved (P < 0.0001), and LUTS resolved in 49/94 patients (52.1%). LUTS improvement correlated with a higher proportion of sensory nerves evoking anal sphincter EMG > 20µV. SDR effectively reduces spasticity, improves motor function, and alleviates LUTS in most children with SCP. Intraoperative neurophysiology may predict improvements, warranting further research.

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