Mitophagy in Ischemic Heart Disease: Molecular Mechanisms and Clinical Management

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2024 Dec 31

PMID 39737905

Authors

Shujuan Xu

Zihan Wang

Fan Guo

Yehao Zhang

Han Peng

Huiyu Zhang

Zixin Liu

Ce Cao

GaoJie Xin

Yuan Yuan Chen

Jianhua Fu

Affiliations

Soon will be listed here.

Abstract

The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The published reviews have not explored in detail the unique function of mitophagy in ischemic heart disease, therefore, the aim of this paper is to summarize how mitophagy regulates the progression of ischemic heart disease. We conclude that mitophagy affects ischemic heart disease by promoting cardiomyocyte hypertrophy and fibrosis, the progression of oxidative stress, the development of inflammation, and cardiomyocyte death, and that the specific mechanisms of mitophagy are worthy of further investigation.

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