T Cell Metabolism in Kidney Immune Homeostasis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Dec 31

PMID 39737193

Authors

Zikang Liu

Binbin Dai

Jiwen Bao

Yangbin Pan

Affiliations

Soon will be listed here.

Abstract

Kidney immune homeostasis is intricately linked to T cells. Inappropriate differentiation, activation, and effector functions of T cells lead to a spectrum of kidney disease. While executing immune functions, T cells undergo a series of metabolic rewiring to meet the rapid energy demand. The key enzymes and metabolites involved in T cell metabolism metabolically and epigenetically modulate T cells' differentiation, activation, and effector functions, thereby being capable of modulating kidney immune homeostasis. In this review, we first summarize the latest advancements in T cell immunometabolism. Second, we outline the alterations in the renal microenvironment under certain kidney disease conditions. Ultimately, we highlight the metabolic modulation of T cells within kidney immune homeostasis, which may shed light on new strategies for treating kidney disease.

References

Nava Lauson C, Tiberti S, Corsetto P, Conte F, Tyagi P, Machwirth M . Linoleic acid potentiates CD8 T cell metabolic fitness and antitumor immunity. Cell Metab. 2023; 35(4):633-650.e9. DOI: 10.1016/j.cmet.2023.02.013. View

Honda T, Hirakawa Y, Nangaku M . The role of oxidative stress and hypoxia in renal disease. Kidney Res Clin Pract. 2019; 38(4):414-426. PMC: 6913586. DOI: 10.23876/j.krcp.19.063. View

Hochrein S, Wu H, Eckstein M, Arrigoni L, Herman J, Schumacher F . The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming. Cell Metab. 2022; 34(4):516-532.e11. PMC: 9019065. DOI: 10.1016/j.cmet.2022.02.015. View

Chen C, Zhang W, Zhou T, Liu Q, Han C, Huang Z . Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell Rep. 2022; 41(9):111741. DOI: 10.1016/j.celrep.2022.111741. View

Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X . Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017; 543(7644):252-256. PMC: 5509051. DOI: 10.1038/nature21379. View

Wabitsch S, McCallen J, Kamenyeva O, Ruf B, McVey J, Kabat J . Metformin treatment rescues CD8 T-cell response to immune checkpoint inhibitor therapy in mice with NAFLD. J Hepatol. 2022; 77(3):748-760. PMC: 9391315. DOI: 10.1016/j.jhep.2022.03.010. View

Noel S, Lee K, Gharaie S, Kurzhagen J, Pierorazio P, Arend L . Immune Checkpoint Molecule TIGIT Regulates Kidney T Cell Functions and Contributes to AKI. J Am Soc Nephrol. 2023; 34(5):755-771. PMC: 10125646. DOI: 10.1681/ASN.0000000000000063. View

Wu Q, Yao Q, Hu T, Yu J, Jiang K, Wan Y . Dapagliflozin protects against chronic heart failure in mice by inhibiting macrophage-mediated inflammation, independent of SGLT2. Cell Rep Med. 2023; 4(12):101334. PMC: 10772464. DOI: 10.1016/j.xcrm.2023.101334. View

Crowl J, Heeg M, Ferry A, Milner J, Omilusik K, Toma C . Tissue-resident memory CD8 T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments. Nat Immunol. 2022; 23(7):1121-1131. PMC: 10041538. DOI: 10.1038/s41590-022-01229-8. View

10.

Bensinger S, Bradley M, Joseph S, Zelcer N, Janssen E, Hausner M . LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008; 134(1):97-111. PMC: 2626438. DOI: 10.1016/j.cell.2008.04.052. View

11.

Lin M, Huang L, Huang J, Yu J, Yang X, Yang J . Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice. J Autoimmun. 2024; 145:103198. DOI: 10.1016/j.jaut.2024.103198. View

12.

Soriano-Baguet L, Brenner D . Metabolism and epigenetics at the heart of T cell function. Trends Immunol. 2023; 44(3):231-244. DOI: 10.1016/j.it.2023.01.002. View

13.

Martins C, New L, OConnor E, Previte D, Cargill K, Tse I . Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4 T Cells in Type 1 Diabetes. Front Immunol. 2021; 12:669456. PMC: 8216385. DOI: 10.3389/fimmu.2021.669456. View

14.

Zhu Z, Hu J, Chen Z, Feng J, Yang X, Liang W . Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming. Metabolism. 2022; 131:155194. DOI: 10.1016/j.metabol.2022.155194. View

15.

Dellepiane S, Leventhal J, Cravedi P . T Cells and Acute Kidney Injury: A Two-Way Relationship. Front Immunol. 2020; 11:1546. PMC: 7379378. DOI: 10.3389/fimmu.2020.01546. View

16.

Thommen D, Schumacher T . T Cell Dysfunction in Cancer. Cancer Cell. 2018; 33(4):547-562. PMC: 7116508. DOI: 10.1016/j.ccell.2018.03.012. View

17.

Lim S, Wei J, Nguyen T, Shi H, Su W, Palacios G . Lipid signalling enforces functional specialization of T cells in tumours. Nature. 2021; 591(7849):306-311. PMC: 8168716. DOI: 10.1038/s41586-021-03235-6. View

18.

Luo Z, Chen Z, Hu J, Ding G . Interplay of lipid metabolism and inflammation in podocyte injury. Metabolism. 2023; 150:155718. DOI: 10.1016/j.metabol.2023.155718. View

19.

Li M, Lai Y, Chen B, Guo C, Zhou M, Zhao S . NAMPT is a metabolic checkpoint of IFNγ-producing CD4 T cells in lupus nephritis. Mol Ther. 2022; 31(1):193-210. PMC: 9840150. DOI: 10.1016/j.ymthe.2022.09.013. View

20.

Feng M, Liu X, Hao X, Ren Y, Dong G, Tian J . Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 Expression. Cancer Res. 2023; 83(20):3368-3384. DOI: 10.1158/0008-5472.CAN-23-0287. View