Research Advances in the Construction of Stem Cell-derived Ovarian Organoids

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2024 Dec 31

PMID 39736770

Authors

Tianyue Zhang

Mengtong Zhang

Sichen Zhang

Shaowei Wang

Affiliations

Soon will be listed here.

Abstract

Ovarian organoids are essential in female reproductive medicine, enhancing our understanding of ovarian diseases and improving treatments, which benefits women's health. Constructing ovarian organoids involves two main processes: differentiating induced pluripotent stem cells (iPSCs) into germ and ovarian somatic cells to restore ovarian function and using extracellular matrix (ECM) to create a suitable ovarian microenvironment and scaffold. Although the technology is still in its early stages, future advancements will likely involve integrating high-throughput analysis, 3D-printed scaffolds, and efficient iPSC induction, driving progress in reproductive and regenerative medicine.

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