Research Hotspots and Trends on NF-κB in Cognitive Impairment: a Bibliometric Analysis

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Dec 30

PMID 39735704

Authors

Lin Bai

Fangyuan Xu

Peijia Hu

Zhiqiang Shen

Su Xingxing

Qingqing Wang

Hongliang Cheng

Affiliations

Soon will be listed here.

Abstract

Background: Cognitive impairment (CI) endangers the physical and mental health of patients in a significant manner, and it is expected that the number of people with CI in China will rise to 45.33 million by 2050. Therefore, CI has become a popular research topic. Inflammatory damage plays a key role in the pathogenesis of CI, and NF-κB is an important inflammatory signaling pathway. However, no bibliometric analysis regarding the relationship between CI and NF-κB has been reported.

Methods: A bibliometric analysis regarding NF-κB and CI from 1 January 2008 to 12 December 2023 was conducted in the Science Citation Index-Expanded of the Web of Science Core Collection. The frontiers, hotspots, and trends of research regarding the role of NF-κB in CI were identified. VOSviewer and CiteSpace were used to analyze the retrieved articles and identify the author, country, institution, and keywords, as well as co-cited authors, co-cited journals, and co-cited references.

Results: We analyzed 1,468 original articles and reviews. Publications on NF-κB in CI began in 2010 and increased sharply in 2018. Hong Hao was the most represented author, having published 19 articles, and Chinese authors published more studies than those from other countries. China Pharmaceutical University published the most papers; however, the United States has a strong influence and demonstrates international cooperation. The keywords "apolipoprotein e" and "therapeutic target" demonstrated strong citation bursts, and this tendency may persist in the upcoming years. Neuroinflammation demonstrated a strong influence in research regarding NF-κB in CI. Gut microbiota and ketogenic diet also play an important role in NF-κB in CI.

Conclusion: This bibliometric analysis and visualization using VOSviewer and CiteSpace revealed that the role of NF-κB in CI has become a research hotspot. The results of this study indicated that "neuroinflammation," "microglial," and "pathway" remain hotspots for future research. However, studies regarding NF-κB in CI have predominantly focussed on basic research; future research should include therapeutic targets, microbiota, and ketogenic diet.

References

Ionescu-Tucker A, Cotman C . Emerging roles of oxidative stress in brain aging and Alzheimer's disease. Neurobiol Aging. 2021; 107:86-95. DOI: 10.1016/j.neurobiolaging.2021.07.014. View

Kunnumakkara A, Shabnam B, Girisa S, Harsha C, Banik K, Devi T . Inflammation, NF-κB, and Chronic Diseases: How are They Linked?. Crit Rev Immunol. 2020; 40(1):1-39. DOI: 10.1615/CritRevImmunol.2020033210. View

Zhang M, Chen H, Zhang W, Liu Y, Ding L, Gong J . Biomimetic Remodeling of Microglial Riboflavin Metabolism Ameliorates Cognitive Impairment by Modulating Neuroinflammation. Adv Sci (Weinh). 2023; 10(12):e2300180. PMC: 10131853. DOI: 10.1002/advs.202300180. View

Soteriades E, Falagas M . Comparison of amount of biomedical research originating from the European Union and the United States. BMJ. 2005; 331(7510):192-4. PMC: 1179763. DOI: 10.1136/bmj.331.7510.192. View

Salthouse T . The processing-speed theory of adult age differences in cognition. Psychol Rev. 1996; 103(3):403-28. DOI: 10.1037/0033-295x.103.3.403. View

Anderson N . State of the science on mild cognitive impairment (MCI). CNS Spectr. 2019; 24(1):78-87. DOI: 10.1017/S1092852918001347. View

Li D, Yu D, Li Y, Yang R . A bibliometric analysis of PROTAC from 2001 to 2021. Eur J Med Chem. 2022; 244:114838. DOI: 10.1016/j.ejmech.2022.114838. View

Taylor R, Sansing L . Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin Dev Immunol. 2013; 2013:746068. PMC: 3810327. DOI: 10.1155/2013/746068. View

Liu Z, Dai X, Zhang H, Shi R, Hui Y, Jin X . Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nat Commun. 2020; 11(1):855. PMC: 7029019. DOI: 10.1038/s41467-020-14676-4. View

10.

Yin Y, Wang Z . ApoE and Neurodegenerative Diseases in Aging. Adv Exp Med Biol. 2018; 1086:77-92. DOI: 10.1007/978-981-13-1117-8_5. View

11.

Lawrence T . The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2010; 1(6):a001651. PMC: 2882124. DOI: 10.1101/cshperspect.a001651. View

12.

Chen G, Liu C, Meng G, Zhang C, Chen F, Tang S . Neuroprotective effect of mogrol against Aβ -induced memory impairment neuroinflammation and apoptosis in mice. J Pharm Pharmacol. 2018; 71(5):869-877. DOI: 10.1111/jphp.13056. View

13.

Tang S, Ren Y, Ren X, Cao J, Hong H, Ji H . ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice. Exp Neurol. 2018; 311:33-43. DOI: 10.1016/j.expneurol.2018.09.002. View

14.

Liu Y, Chen C, Zhou Y, Zhang N, Liu S . Twenty years of research on borderline personality disorder: a scientometric analysis of hotspots, bursts, and research trends. Front Psychiatry. 2024; 15:1361535. PMC: 10941281. DOI: 10.3389/fpsyt.2024.1361535. View

15.

Siervo M, Babateen A, Alharbi M, Stephan B, Shannon O . Dietary nitrate and brain health. Too much ado about nothing or a solution for dementia prevention?. Br J Nutr. 2023; 128(6):1130-1136. DOI: 10.1017/S0007114522002434. View

16.

Tangalos E, Petersen R . Mild Cognitive Impairment in Geriatrics. Clin Geriatr Med. 2018; 34(4):563-589. DOI: 10.1016/j.cger.2018.06.005. View

17.

Xu L, He D, Bai Y . Microglia-Mediated Inflammation and Neurodegenerative Disease. Mol Neurobiol. 2015; 53(10):6709-6715. DOI: 10.1007/s12035-015-9593-4. View

18.

Rosenberg G . Extracellular matrix inflammation in vascular cognitive impairment and dementia. Clin Sci (Lond). 2017; 131(6):425-437. DOI: 10.1042/CS20160604. View

19.

Wang H, Zhang M, Li J, Liang J, Yang M, Xia G . Gut microbiota is causally associated with poststroke cognitive impairment through lipopolysaccharide and butyrate. J Neuroinflammation. 2022; 19(1):76. PMC: 8981610. DOI: 10.1186/s12974-022-02435-9. View

20.

Sun Y, Baptista L, Roberts L, Jumbo-Lucioni P, McMahon L, Buford T . The Gut Microbiome as a Therapeutic Target for Cognitive Impairment. J Gerontol A Biol Sci Med Sci. 2019; 75(7):1242-1250. PMC: 7302188. DOI: 10.1093/gerona/glz281. View