Novel Transition Metal-free Synthetic Protocols Toward the Construction of 2,3-dihydrobenzofurans: a Recent Update

Overview

Journal Front Chem

Specialty Chemistry

Date 2024 Dec 30

PMID 39734577

Authors

Aqsa Mushtaq

Muhammad Irfan

Atta Ul Haq

Asim Mansha

Samreen Gul Khan

Ameer Fawad Zahoor

Bushra Parveen

Ali Irfan

Katarzyna Kotwica-Mojzych

Mariola Glowacka

Mariusz Mojzych

Affiliations

Soon will be listed here.

Abstract

2,3-Dihydrobenzofurans are noteworthy scaffolds in organic and medicinal chemistry, constituting the structural framework of many of the varied medicinally active organic compounds. Moreover, a diverse variety of biologically potent natural products also contain this heterocyclic nucleus. Reflecting on the wide biological substantiality of dihydrobenzofurans, several innovative and facile synthetic developments are evolving to achieve these heterocycles. This review summarizes the transition-metal-free, efficient, and novel synthetic pathways toward constructing the dihydrobenzofuran nucleus established after 2020.

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