Interplay and Therapeutic Implications of Colorectal Cancer Stem Cells, Tumor Microenvironment, and Gut Microbiota

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2024 Dec 30

PMID 39734482

Authors

Hui Zhang

Bo-Tao Xu

Di-Ping Luo

Tie-Fei He

Affiliations

Soon will be listed here.

Abstract

This article discusses the interplay between colorectal cancer (CRC) stem cells, tumor microenvironment (TME), and gut microbiota, emphasizing their dynamic roles in cancer progression and treatment resistance. It highlights the adaptability of CRC stem cells, the bidirectional influence of TME, and the multifaceted impact of gut microbiota on CRC. The manuscript proposes innovative therapeutic strategies focusing on these interactions, advocating for a shift towards personalized and ecosystem-targeted treatments in CRC. The conclusion underscores the importance of continued research in these areas for developing effective, personalized therapies.

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