Impact of Unintentional Weight Loss on 30-day Mortality in Intensive Care Unit Sepsis Patients: a Retrospective Cohort Study

Overview

Journal Sci Rep

Specialty Science

Date 2024 Dec 29

PMID 39733192

Authors

Weide Lin

Bixia Lin

JunFan Chen

Renwei Li

Yaohua Yu

Shiqing Huang

Shurong Li

Jing Lin

Affiliations

Soon will be listed here.

Abstract

This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20-2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU.

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