Acanthamoeba Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification

Overview

Journal Transpl Infect Dis

Specialties General Surgery
Infectious Diseases

Date 2024 Dec 28

PMID 39731681

Authors

Camellia T Banerjee

Sean Conlan

Anahita Mostaghim

Angela Michelin

Matthew Arduino

Mia Mattioli

Julia C Haston

Sanchita Das

Amir Seyedmousavi

Bickey H Chang

Elise M OConnell

Christopher G Kanakry

Akbulut Dilara

Martha Quezado

Juan Gea-Banacloche

Clay Deming

Julia A Segre

Alison Han

Jennifer Cuellar-Rodriguez

Affiliations

Soon will be listed here.

Abstract

We report a case of Acanthamoeba infection in an HCT recipient with steroid-refractory GVHD. We highlight the multiple challenges that free-living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include Acanthamoeba infections in their differential diagnosis of a patient with skin, sinus, lung, and/or brain involvement.

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