Undetected Circulation of Major Arboviruses in West Sudan: Urging for Institutionalizing Multisectoral One Health Strategy for the Preparedness, Prevention, and Control of Zoonotic Arboviral Diseases

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2024 Dec 26

PMID 39726037

Authors

Nouh Saad Mohamed

Emmanuel Edwar Siddig

Claude Mambo Muvunyi

Abdualmoniem Omer Musa

Adel Elduma

Ayman Ahmed

Affiliations

Soon will be listed here.

Abstract

Objectives: Arboviruses pose a significant global health challenge. This study investigated the seroprevalence of major human arboviral infections, including yellow fever (YFV), dengue (DENV), Crimean-Congo hemorrhagic fever (CCHF), Rift Valley fever (RVF), West Nile virus (WNV), and chikungunya (CHIK), in Darfur region from September to December 2018. ELISA-IgM was used to detect antibodies. RT‒PCR was used to differentiate YFV infection from vaccine-immuno-response in IgM samples.

Results: A total of 152 blood samples were collected, with 123 (80.9%) from males and 29 (19.1%) from females. The participants were grouped by age: 50 (32.9%) were under 20 years, 96 (63.2%) were aged 20-45 years, and 6 (3.9%) were over 45 years. The seroprevalence rates for YFV, DENV, and CHIKV were 68 (44.7%), 23 (15.1%), and 5 (3.3%), respectively. There were 11 molecularly-confirmed YFV cases (7.2%). Among these, 3/11 were positive for DENV-IgM, and 1/11 was positive for CHIKV-IgM. Among the 68 YFV-positive individuals, 15 (22.1%) had been exposed to DENV, and 2 (2.9%) had been exposed to CHIKV. Co-exposure to DENV and CHIKV was detected in 3 (1.9%) patients, while 2 (1.3%) patients had triple exposure to YFV, CHIKV, or DENV. No exposure to CCHF, RVFV, or WNV was detected.

Citing Articles

Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy.

Muvunyi C, Ngabonziza J, Siddig E, Ahmed A Microorganisms. 2025; 13(1).

PMID: 39858859 PMC: 11768005. DOI: 10.3390/microorganisms13010091.

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