The Monogenic Landscape of Human Infectious Diseases

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2024 Dec 26

PMID 39724971

Authors

Stephanie Boisson-Dupuis

Paul Bastard

Vivien Beziat

Jacinta Bustamante

Aurelie Cobat

Emmanuelle Jouanguy

Anne Puel

Jeremie Rosain

Qian Zhang

Shen-Ying Zhang

Bertrand Boisson

Affiliations

Soon will be listed here.

Abstract

The spectrum of known monogenic inborn errors of immunity is growing, with certain disorders underlying a specific and narrow range of infectious diseases. These disorders reveal the core mechanisms by which these infections occur in various settings, including inherited and acquired immunodeficiencies, thereby delineating the essential mechanisms of protective immunity to the corresponding pathogens. These findings also have medical implications, facilitating diagnosis and improving the management of individuals at risk of disease.

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