Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2024 Dec 26

PMID 39723698

Authors

Kohei Ohnishi

Takaaki Sokabe

Affiliations

Soon will be listed here.

Abstract

In this review, we introduce the concept of "dual thermosensing mechanisms," highlighting the functional collaboration between G protein-coupled receptors (GPCRs) and transient receptor potential (TRP) channels that enable sophisticated cellular thermal responsiveness. GPCRs have been implicated in thermosensory processes, with recent findings identifying several candidates across species, including mammals, fruit flies, and nematodes. In many cases, these GPCRs work in conjunction with another class of thermosensors, TRP channels, offering insights into the complex mechanisms underlying thermosensory signaling. We examine how GPCRs function as thermosensors and how their signaling regulates cellular thermosensation, illustrating the complexity of thermosensory systems. Understanding these dual thermosensory mechanisms would advance our comprehension of cellular thermosensation and its regulatory pathways.

References

HODGKIN A, HUXLEY A . Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J Physiol. 1952; 116(4):449-72. PMC: 1392213. DOI: 10.1113/jphysiol.1952.sp004717. View

Latorraca N, Venkatakrishnan A, Dror R . GPCR Dynamics: Structures in Motion. Chem Rev. 2016; 117(1):139-155. DOI: 10.1021/acs.chemrev.6b00177. View

Miyamoto S, Hori M, Izumi M, Ozaki H, Karaki H . Species- and temperature-dependency of the decrease in myofilament Ca2+ sensitivity induced by beta-adrenergic stimulation. Jpn J Pharmacol. 2001; 85(1):75-83. DOI: 10.1254/jjp.85.75. View

Reinhardt D, Butzheinen R, Brodde O, SCHUMANN H . The role of cyclic AMP in temperature-dependent changes of contractile force and sensitivity ot isoprenaline and papaverine in guinea-pig atria. Eur J Pharmacol. 1978; 48(1):107-16. DOI: 10.1016/0014-2999(78)90048-1. View

Bautista D, Jordt S, Nikai T, Tsuruda P, Read A, Poblete J . TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006; 124(6):1269-82. DOI: 10.1016/j.cell.2006.02.023. View

Knapp B, Huang K . The Effects of Temperature on Cellular Physiology. Annu Rev Biophys. 2022; 51:499-526. DOI: 10.1146/annurev-biophys-112221-074832. View

Catterall W . From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron. 2000; 26(1):13-25. DOI: 10.1016/s0896-6273(00)81133-2. View

Glauser D . Temperature sensing and context-dependent thermal behavior in nematodes. Curr Opin Neurobiol. 2022; 73:102525. DOI: 10.1016/j.conb.2022.102525. View

Kang D, Choe C, Kim D . Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol. 2005; 564(Pt 1):103-16. PMC: 1456046. DOI: 10.1113/jphysiol.2004.081059. View

10.

Neves S, Ram P, Iyengar R . G protein pathways. Science. 2002; 296(5573):1636-9. DOI: 10.1126/science.1071550. View

11.

Zimmermann K, Leffler A, Babes A, Cendan C, Carr R, Kobayashi J . Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature. 2007; 447(7146):855-8. DOI: 10.1038/nature05880. View

12.

Takeishi A, Takagaki N, Kuhara A . Temperature signaling underlying thermotaxis and cold tolerance in . J Neurogenet. 2020; 34(3-4):351-362. DOI: 10.1080/01677063.2020.1734001. View

13.

Honore E . The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci. 2007; 8(4):251-61. DOI: 10.1038/nrn2117. View

14.

Kohno K, Sokabe T, Tominaga M, Kadowaki T . Honey bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of transient receptor potential channel genes. J Neurosci. 2010; 30(37):12219-29. PMC: 6633439. DOI: 10.1523/JNEUROSCI.2001-10.2010. View

15.

Catterall W, Goldin A, Waxman S . International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev. 2005; 57(4):397-409. DOI: 10.1124/pr.57.4.4. View

16.

Clapham D, Montell C, Schultz G, Julius D . International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. Pharmacol Rev. 2003; 55(4):591-6. DOI: 10.1124/pr.55.4.6. View

17.

Gu P, Gong J, Shang Y, Wang F, Ruppell K, Ma Z . Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. 2019; 29(23):3961-3973.e6. PMC: 6938258. DOI: 10.1016/j.cub.2019.09.070. View

18.

Hardie R, Juusola M . Phototransduction in Drosophila. Curr Opin Neurobiol. 2015; 34:37-45. DOI: 10.1016/j.conb.2015.01.008. View

19.

Montell C, Birnbaumer L, Flockerzi V, Bindels R, Bruford E, Caterina M . A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002; 9(2):229-31. DOI: 10.1016/s1097-2765(02)00448-3. View

20.

Glauser D, Chen W, Agin R, MacInnis B, Hellman A, Garrity P . Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans. Genetics. 2011; 188(1):91-103. PMC: 3120139. DOI: 10.1534/genetics.111.127100. View