Structural and Functional Projections of the Nucleus Basalis of Meynert and Their Changes After Cognitive Training in Individuals With Mild Cognitive Impairment

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2024 Dec 26

PMID 39723443

Authors

Qingzheng Lu

Yu Wang

Bingqian Qu

Caixia Wang

Xiao Su

Siqi Wang

Yi Xing

Wen Qin

Yi Tang

Nan Zhang

Affiliations

Soon will be listed here.

Abstract

Aims: The nucleus basalis of Meynert (NBM) is a major source of cholinergic innervation in the central nervous system. We aimed to investigate the characteristics of structural and functional alterations in the NBM and its projections in patients with mild cognitive impairment (MCI) and the effects of computerized cognitive training (CCT).

Methods: Forty-five patients with MCI and 45 cognitively unimpaired controls (CUCs) were recruited. NBM volume, mean diffusivity (MD) of NBM white matter (WM) projections, and functional connectivity (FC) of projections of the NBM were measured with T1-weighted imaging, diffusion tensor imaging (DTI), and resting-state functional magnetic resonance imaging (rs-fMRI). Thirty-six MCI patients were randomly assigned to receive CCT or control training. The effects of CCT on the neuropsychological measures and MRI properties were analyzed with a linear mixed model (LMM).

Results: We detected that compared with the CUCs, the MCI patients had a reduced volume of the NBM and a greater MD of both cholinergic pathways. Increased MD values of both pathways were related to lower scores of global cognition, processing speed and attention in all participants. After CCT intervention, significant group × timepoint effects on score of the Backward Digit Span and the FC between NBM and right putamen were observed in the CCT group compared to the control group.

Conclusion: NBM atrophy and WM pathway disruption occurred in MCI patients and were correlated with cognitive impairment. Working memory and the FC between NBM and right putamen could be improved by cognitive training.

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