» Articles » PMID: 39723293

Skin Metastasis From Solid Tumors: Is Targeted Therapy Making an Impact?

Overview
Journal Cureus
Date 2024 Dec 26
PMID 39723293
Authors
Affiliations
Soon will be listed here.
Abstract

Cutaneous metastasis from solid tumors is a rare manifestation that presents in the clinic. It is usually indicative of poor prognosis, with a poor response to conventional chemotherapy. The introduction of targeted therapy has changed the treatment paradigm in oncology, improving the quality of life and survival of all cancer patients. Here, we present two cases of solid tumors with skin metastases that had a good response to targeted systemic therapy. This case report also discusses the various modes of presentation and the therapeutic options for metastatic cutaneous lesions from solid tumors.

References
1.
Lookingbill D, Spangler N, Helm K . Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993; 29(2 Pt 1):228-36. DOI: 10.1016/0190-9622(93)70173-q. View

2.
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H . Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010; 362(25):2380-8. DOI: 10.1056/NEJMoa0909530. View

3.
Valastyan S, Weinberg R . Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011; 147(2):275-92. PMC: 3261217. DOI: 10.1016/j.cell.2011.09.024. View

4.
Queiros C, Filipe P, Soares de Almeida L . Cutaneous metastases from solid neoplasms in the 21st century: a retrospective study from a Portuguese tertiary care center. J Eur Acad Dermatol Venereol. 2019; 34(6):1218-1224. DOI: 10.1111/jdv.16120. View

5.
Saeed S, Keehn C, Morgan M . Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal. J Cutan Pathol. 2004; 31(6):419-30. DOI: 10.1111/j.0303-6987.2004.00207.x. View