Impact of Weekly Community-Based Dance Training Over 8 Months on Depression and Blood Oxygen Level-Dependent Signals in the Subcallosal Cingulate Gyrus for People With Parkinson Disease: Observational Study

Overview

Journal JMIRx Med

Publisher JMIR Publications

Specialty Medical Informatics

Date 2024 Dec 25

PMID 39722122

Authors

Karolina A Bearss

Rebecca E Barnstaple

Rachel J Bar

Joseph F X DeSouza

Affiliations

Soon will be listed here.

Abstract

Background: Dance has emerged as a complementary treatment that may promote adaptive neural plasticity while improving symptoms of Parkinson disease (PD), such as balance, gait, posture, and walking. Understanding brain changes that arise from participation in dance interventions is important as these neural plastic changes play an important role in protecting and healing the brain. Although dance has been shown to improve PD motor and nonmotor symptoms, the neural mechanisms underlying these changes, specifically depression and mood, remain elusive. Further, many side effects of PD drug treatments can be exacerbated or even induced by dopaminergic drugs, particularly depression and anxiety, making these nonmotor symptoms more noticeable throughout the progression of the disease.

Objective: In this study, we focused on the impact of dance interventions on PD nonmotor symptoms by conducting an 8-month observational study, tracking the relationship between depression scores and functional neuroimaging measures for people with PD.

Methods: A total of 34 dancers-23 (68%) people with PD and 11 (32%) healthy controls-completed the Geriatric Depression Scale (GDS) before and after attending weekly community-based dance classes, referred to as Dance for PD classes. Specifically, we examined changes within the functional magnetic resonance imaging signal from the subcallosal cingulate gyrus (SCG), an important node within the depression network and a controversial target for deep brain stimulation in the treatment of major depressive disorder.

Results: Depression scores on the GDS decreased in each preintervention to postintervention comparison (all P<.025). In addition, GDS scores also improved over the 8-month dance period (all P<.01). Blood oxygen level-dependent signals from frontal cortex brain region implicated for emotional regulation within the SCG decreased at each testing time point (all P<.05). Also, a significant decrease in depression scores (GDS) was correlated with reduced blood oxygen level-dependent signals from the SCG (P=.02).

Conclusions: This study contributes to an improved understanding of the neural mechanisms that are involved in depression, as well as the beneficial contribution that longitudinal dance interventions have in reducing nonmotor symptoms associated with PD, particularly in depression symptoms.

References

Fava M, Rankin M, Wright E, Alpert J, Nierenberg A, Pava J . Anxiety disorders in major depression. Compr Psychiatry. 2000; 41(2):97-102. DOI: 10.1016/s0010-440x(00)90140-8. View

Mayberg H, Lozano A, Voon V, McNeely H, Seminowicz D, Hamani C . Deep brain stimulation for treatment-resistant depression. Neuron. 2005; 45(5):651-60. DOI: 10.1016/j.neuron.2005.02.014. View

Hashimoto H, Takabatake S, Miyaguchi H, Nakanishi H, Naitou Y . Effects of dance on motor functions, cognitive functions, and mental symptoms of Parkinson's disease: a quasi-randomized pilot trial. Complement Ther Med. 2015; 23(2):210-9. DOI: 10.1016/j.ctim.2015.01.010. View

Hackney M, Earhart G . Effects of dance on gait and balance in Parkinson's disease: a comparison of partnered and nonpartnered dance movement. Neurorehabil Neural Repair. 2009; 24(4):384-92. PMC: 2900796. DOI: 10.1177/1545968309353329. View

Houston S, McGill A . A mixed-methods study into ballet for people living with Parkinson's. Arts Health. 2013; 5(2):103-119. PMC: 3687249. DOI: 10.1080/17533015.2012.745580. View

Savica R, Rocca W, Ahlskog J . When does Parkinson disease start?. Arch Neurol. 2010; 67(7):798-801. DOI: 10.1001/archneurol.2010.135. View

Koch S, Mergheim K, Raeke J, Machado C, Riegner E, Nolden J . The Embodied Self in Parkinson's Disease: Feasibility of a Single Tango Intervention for Assessing Changes in Psychological Health Outcomes and Aesthetic Experience. Front Neurosci. 2016; 10:287. PMC: 4935674. DOI: 10.3389/fnins.2016.00287. View

Bastide M, Meissner W, Picconi B, Fasano S, Fernagut P, Feyder M . Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Prog Neurobiol. 2015; 132:96-168. DOI: 10.1016/j.pneurobio.2015.07.002. View

Moncrieff J, Cooper R, Stockmann T, Amendola S, Hengartner M, Horowitz M . The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2022; 28(8):3243-3256. PMC: 10618090. DOI: 10.1038/s41380-022-01661-0. View

10.

Kalyani H, Sullivan K, Moyle G, Brauer S, Jeffrey E, Kerr G . Impacts of dance on cognition, psychological symptoms and quality of life in Parkinson's disease. NeuroRehabilitation. 2019; 45(2):273-283. DOI: 10.3233/NRE-192788. View

11.

Weintraub D, Somogyi M, Meng X . Rivastigmine in Alzheimer's disease and Parkinson's disease dementia: an ADAS-cog factor analysis. Am J Alzheimers Dis Other Demen. 2011; 26(6):443-9. PMC: 10845532. DOI: 10.1177/1533317511424892. View

12.

Rudebeck P, Putnam P, Daniels T, Yang T, Mitz A, Rhodes S . A role for primate subgenual cingulate cortex in sustaining autonomic arousal. Proc Natl Acad Sci U S A. 2014; 111(14):5391-6. PMC: 3986148. DOI: 10.1073/pnas.1317695111. View

13.

Hamani C, Mayberg H, Snyder B, Giacobbe P, Kennedy S, Lozano A . Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting. J Neurosurg. 2009; 111(6):1209-15. DOI: 10.3171/2008.10.JNS08763. View

14.

Parkinson J . An essay on the shaking palsy. 1817. J Neuropsychiatry Clin Neurosci. 2002; 14(2):223-36; discussion 222. DOI: 10.1176/jnp.14.2.223. View

15.

Forouzanfar M, Alexander L, Anderson H, Bachman V, Biryukov S, Brauer M . Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015; 386(10010):2287-323. PMC: 4685753. DOI: 10.1016/S0140-6736(15)00128-2. View

16.

Dalle E, Mabandla M . Early Life Stress, Depression And Parkinson's Disease: A New Approach. Mol Brain. 2018; 11(1):18. PMC: 5858138. DOI: 10.1186/s13041-018-0356-9. View

17.

Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano A . The subcallosal cingulate gyrus in the context of major depression. Biol Psychiatry. 2010; 69(4):301-8. DOI: 10.1016/j.biopsych.2010.09.034. View

18.

Bar R, DeSouza J . Tracking Plasticity: Effects of Long-Term Rehearsal in Expert Dancers Encoding Music to Movement. PLoS One. 2016; 11(1):e0147731. PMC: 4732757. DOI: 10.1371/journal.pone.0147731. View

19.

Westheimer O, McRae C, Henchcliffe C, Fesharaki A, Glazman S, Ene H . Dance for PD: a preliminary investigation of effects on motor function and quality of life among persons with Parkinson's disease (PD). J Neural Transm (Vienna). 2015; 122(9):1263-70. DOI: 10.1007/s00702-015-1380-x. View

20.

Roet M, Boonstra J, Sahin E, Mulders A, Leentjens A, Jahanshahi A . Deep Brain Stimulation for Treatment-Resistant Depression: Towards a More Personalized Treatment Approach. J Clin Med. 2020; 9(9). PMC: 7565181. DOI: 10.3390/jcm9092729. View