Long Non-coding RNAs Are Involved in the Crosstalk Between Cancer-associated Fibroblasts and Tumor Cells

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Dec 24

PMID 39717771

Authors

Chenbo Yang

Jiao Shu

Yiwei Li

Na Zhao

Xiaonan Liu

Xiangyu Tian

Zexin Sun

Muhammad Saud Tabish

Yichen Hong

Kuisheng Chen

Miaomiao Sun

Affiliations

Soon will be listed here.

Abstract

The proliferation of tumors is not merely self-regulated by the cancer cells but is also intrinsically connected to the tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in the modulation of tumor onset and progression. Rich signaling interactions exist between CAFs and tumor cells, which are crucial for tumor regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class of functionally diverse RNA molecules. Recent studies have revealed that LncRNAs are integral to the crosstalk between CAFs and tumor cells, with the capacity to modify cellular transcriptional activity and secretion profiles, thus facilitating CAFs activation, tumor proliferation, metastasis, drug resistance, and other related functionalities. This comprehensive review revisits the latest research on LncRNA-mediated interactions between CAFs and tumor cells, encapsulates the biological roles of LncRNAs, and delves into the molecular pathways from a broader perspective, aspiring to offer novel perspectives for a deeper comprehension of the etiology of tumors and the enhancement of therapeutic approaches.

References

Zhao L, Ji G, Le X, Wang C, Xu L, Feng M . Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer. Cancer Res. 2017; 77(6):1369-1382. DOI: 10.1158/0008-5472.CAN-16-1615. View

Kalluri R, McAndrews K . The role of extracellular vesicles in cancer. Cell. 2023; 186(8):1610-1626. PMC: 10484374. DOI: 10.1016/j.cell.2023.03.010. View

Arina A, Idel C, Hyjek E, Alegre M, Wang Y, Bindokas V . Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016; 113(27):7551-6. PMC: 4941507. DOI: 10.1073/pnas.1600363113. View

Zhang P, Wang Q, Lu W, Zhang F, Wu D, Sun J . NNT-AS1 in CAFs-derived exosomes promotes progression and glucose metabolism through miR-889-3p/HIF-1α in pancreatic adenocarcinoma. Sci Rep. 2024; 14(1):6979. PMC: 10960871. DOI: 10.1038/s41598-024-57769-6. View

Camuzard O, Santucci-Darmanin S, Carle G, Pierrefite-Carle V . Autophagy in the crosstalk between tumor and microenvironment. Cancer Lett. 2020; 490:143-153. DOI: 10.1016/j.canlet.2020.06.015. View

Zhao J, Yang S, Lv C, Liu Y . Cancer-associated fibroblasts suppressed ferroptosis in glioblastoma via upregulating lncRNA DLEU1. Am J Physiol Cell Physiol. 2023; 324(5):C1039-C1052. DOI: 10.1152/ajpcell.00454.2022. View

Yang P, Zhang D, Wang T, Ji J, Jin C, Peng C . CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway. Cell Death Dis. 2022; 13(9):796. PMC: 9485119. DOI: 10.1038/s41419-022-05240-7. View

Dunbar K, Wong K, Rustgi A . Cancer-Associated Fibroblasts in Esophageal Cancer. Cell Mol Gastroenterol Hepatol. 2024; 17(5):687-695. PMC: 10958110. DOI: 10.1016/j.jcmgh.2024.01.008. View

Fan J, Zhou Z, Luo Y, Luo Q, Chen S, Zhao J . Exosomal lncRNA NEAT1 from cancer-associated fibroblasts facilitates endometrial cancer progression via miR-26a/b-5p-mediated STAT3/YKL-40 signaling pathway. Neoplasia. 2021; 23(7):692-703. PMC: 8233173. DOI: 10.1016/j.neo.2021.05.004. View

10.

Zhang Y, Luo G, You S, Zhang L, Liang C, Chen X . Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis. Acta Biochim Biophys Sin (Shanghai). 2021; 53(6):673-682. DOI: 10.1093/abbs/gmab041. View

11.

Huang C, Liu J, He L, Wang F, Xiong B, Li Y . The long noncoding RNA noncoding RNA activated by DNA damage (NORAD)-microRNA-496-Interleukin-33 axis affects carcinoma-associated fibroblasts-mediated gastric cancer development. Bioengineered. 2021; 12(2):11738-11755. PMC: 8810175. DOI: 10.1080/21655979.2021.2009412. View

12.

Fang L, Zhang M, Li J, Zhou L, Tamm M, Roth M . Airway Smooth Muscle Cell Mitochondria Damage and Mitophagy in COPD via ERK1/2 MAPK. Int J Mol Sci. 2022; 23(22). PMC: 9694999. DOI: 10.3390/ijms232213987. View

13.

Li T, Tian L, Cao J, Liu M . Cancer-associated fibroblasts secret extracellular vesicles to support cell proliferation and epithelial-mesenchymal transition in laryngeal squamous cell carcinoma. Mol Cell Probes. 2023; 72:101934. DOI: 10.1016/j.mcp.2023.101934. View

14.

Luo G, Zhang Y, Wu Z, Zhang L, Liang C, Chen X . Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis. Acta Biochim Biophys Sin (Shanghai). 2021; 53(5):558-566. DOI: 10.1093/abbs/gmab023. View

15.

Bray F, Laversanne M, Sung H, Ferlay J, Siegel R, Soerjomataram I . Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024; 74(3):229-263. DOI: 10.3322/caac.21834. View

16.

Peng D, Fu M, Wang M, Wei Y, Wei X . Targeting TGF-β signal transduction for fibrosis and cancer therapy. Mol Cancer. 2022; 21(1):104. PMC: 9033932. DOI: 10.1186/s12943-022-01569-x. View

17.

Monti N, Verna R, Piombarolo A, Querqui A, Bizzarri M, Fedeli V . Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory. Biomolecules. 2022; 12(5). PMC: 9138429. DOI: 10.3390/biom12050662. View

18.

Zeng H, Hou Y, Zhou X, Lang L, Luo H, Sun Y . Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer. Theranostics. 2022; 12(17):7351-7370. PMC: 9691361. DOI: 10.7150/thno.74753. View

19.

Kalluri R, Weinberg R . The basics of epithelial-mesenchymal transition. J Clin Invest. 2009; 119(6):1420-8. PMC: 2689101. DOI: 10.1172/JCI39104. View

20.

Liao Z, Tan Z, Zhu P, Tan N . Cancer-associated fibroblasts in tumor microenvironment - Accomplices in tumor malignancy. Cell Immunol. 2018; 343:103729. DOI: 10.1016/j.cellimm.2017.12.003. View